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Article
The application of SFDI and LSI system to evaluate the blood perfusion in skin flap mouse model
The aim of this study is to evaluate whether the blood perfusion to tissues for detecting ischemic necrosis can be quantitatively monitored by spatial frequency domain imaging (SFDI) and laser speckle imaging ...
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Article
Open AccessActivation of matrix metalloproteinases and FoxO3a in HaCaT keratinocytes by radiofrequency electromagnetic field exposure
As the skin is the largest body organ and critically serves as a barrier, it is frequently exposed and could be physiologically affected by radiofrequency electromagnetic field (RF-EMF) exposure. In this study...
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Article
Open AccessFAM83H is involved in stabilization of β-catenin and progression of osteosarcomas
FAM83H was initially identified as a protein essential for dental enamel formation. Recent reports have shown that FAM83H is also involved in the progression of human cancers in conjunction with tumor-associat...
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Article
Open AccessExpression of oxidized protein tyrosine phosphatase and γH2AX predicts poor survival of gastric carcinoma patients
Oxidative stress induces various intracellular damage, which might be correlated with tumorigenesis. Accumulated oxidative stresses might inactivate protein tyrosine phosphatase (PTP) by oxidizing it, and indu...
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Article
Open AccessThe PARP inhibitor olaparib potentiates the effect of the DNA damaging agent doxorubicin in osteosarcoma
PARP1 facilitates the recovery of DNA-damaged cells by recruiting DNA damage response molecules such as γH2AX and BRCA1/2, and plays a role in resistance to antitumor therapies. Therefore, PARP inhibition bein...
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Article
Open AccessFAM83H is involved in the progression of hepatocellular carcinoma and is regulated by MYC
Recently, the roles of FAM83H in tumorigenesis have been interested and increased expression of FAM83H and MYC in hepatocellular carcinoma (HCC) have been reported. Therefore, we investigated the expression an...
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Article
Open AccessXXIV World Allergy Congress 2015
A1 Pirfenidone inhibits TGF-b1-induced extracellular matrix production in nasal polyp-derived fibroblasts
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Article
Open AccessDBC1/CCAR2 is involved in the stabilization of androgen receptor and the progression of osteosarcoma
Deleted in breast cancer 1 (DBC1/CCAR2) is a protein of interest because of its diverse roles in tumorigenesis and its possible role as an androgen receptor (AR) co-activator. However, there are limited studie...
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Article
Open AccessExpression of nerve growth factor and heme oxygenase-1 predict poor survival of breast carcinoma patients
Nerve growth factor (NGF) is a neurotrophin and has been suggested to induce heme oxygenase-1 (HO1) expression. Although the role of HO1 in tumorigenesis remains controversial, recent evidence suggests NGF and...
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Article
Cross-linking of CD137 ligand modulates immune responses of thioglycollate-elicited mouse peritoneal macrophages
The aim of this study was to investigate effects of CD137 ligand (CD137L)-mediated reverse signaling on cellular responses in thioglycollate-elicited mouse peritoneal macrophages.
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Article
Effect of Phellinus linteus extract supplementation on cortisol and related cytokines in young male adults
This study investigated the anti-inflammatory effects of Pellinus linteus (PL) extract supplementation in healthy young men. The subjects were 18 healthy young males 20 years of age that were given 1.5 L of 0.12%...
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Article
Tropical Malaysians and temperate Koreans exhibit significant differences in sweating sensitivity in response to iontophoretically administered acetylcholine
Natives of the tropics are able to tolerate high ambient temperatures. This results from their long-term residence in hot and often humid tropical climates. This study was designed to compare the peripheral me...
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Article
Beneficial effects of cardiac rehabilitation and exercise after percutaneous coronary intervention on hsCRP and inflammatory cytokines in CAD patients
Recent studies showed that tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6), as well as high-sensitive C-reactive protein (hsCRP) levels are predictive factors of cardiovascular risk. However, the effe...
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Article
Effects of anesthetic agents on cellular 123I-MIBG transport and in vivo 123I-MIBG biodistribution
Small animal imaging with meta-iodobenzylguanidine (MIBG) allows characterization of animal models, optimization of tumor treatment strategies, and monitoring of gene expression. Anesthetic agents, however, ca...
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Article
Prolonged residence of temperate natives in the tropics produces a suppression of sweating
Tropical natives possess heat tolerance due to the ability to off-load endogenous and exogenous heat efficiently using a minimum amount of sweat. On the other hand, exposure of temperate natives to heat result...
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Article
Pharmacokinetics and biodistribution of a small radioiodine labeled nerve growth factor fragment
Nerve growth factor (NGF) exerts various actions on neuronal and non-neuronal tissues and has potential therapeutic utility, but difficulties in using the whole protein have stimulated interest in small NGF fr...
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Article
Anticancer efficacies of doxorubicin, verapamil and quercetin on FM3A cells under hyperthermic temperature
Hyperthermia (HT) in combination with anticancer drugs (ACDs) had proven to more efficacious in various cancers, although efficacies vary according to chemotherapeutic compounds and cancer types. Presently the...
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Article
Insecticidal toxin fromXenorhabdus nematophilus, symbiotic bacterium associated with entomopathogenic nematodeSteinernema glaseri
Entomopathogenic nematodes are being used for insect control. We purified a toxin secreted by the insect-pathogenic bacterium,Xenorhabdus nematophilus, which lives in the gut of entomopathogenic nematodes. Cultur...
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Article
Extracellular protease production fromXenorhabdus nematophilus, a symbiotic bacterium of entomopathogenic nematodes
Effects of nutrients and growth temperature on the production of an extracellular protease fromXenorhabdus nematophilus, a symbiotic bacterium of entomopathogenic nematodes were studied for batch culture. Trypton...
