7 Result(s)
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Julio C. B. Ferreira
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Open AccessAuthor Correction: A selective inhibitor of mitofusin 1-βIIPKC association improves heart failure outcome in rats
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Metabolic dysfunction induced by HFD + L-NAME preferentially affects hippocampal mitochondria, impacting spatial memory in rats
High-fat diet-induced metabolic changes are not restricted to the onset of cardiovascular diseases, but also include effects on brain functions related to learning and memory. This study aimed to evaluate mito...
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Mitochondrial Biogenesis and Dynamics in Health and Disease
Mitochondria control a myriad of intracellular processes including ATP synthesis, redox balance, ion homeostasis and metabolism of amino acids and lipids. Maintaining a healthy and demand-matched pool of mitoc...
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Open AccessA selective inhibitor of mitofusin 1-βIIPKC association improves heart failure outcome in rats
We previously demonstrated that beta II protein kinase C (βIIPKC) activity is elevated in failing hearts and contributes to this pathology. Here we report that βIIPKC accumulates on the mitochondrial outer mem...
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ALDH2 and Cardiovascular Disease
Aldehyde dehydrogenase 2 (ALDH2) is a non-cytochrome P450 mitochondrial aldehyde oxidizing enzyme. It is best known for its role in the metabolism of acetaldehyde, a common metabolite from alcohol drinking. Mo...
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Open AccessExercise prevents impaired autophagy and proteostasis in a model of neurogenic myopathy
Increased proteolytic activity has been widely associated with skeletal muscle atrophy. However, elevated proteolysis is also critical for the maintenance of cellular homeostasis by disposing cytotoxic protein...
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Open AccessNew therapeutics to modulate mitochondrial dynamics and mitophagy in cardiac diseases
The processes that control the number and shape of the mitochondria (mitochondrial dynamics) and the removal of damaged mitochondria (mitophagy) have been the subject of intense research. Recent work indicates...
