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Article
Open AccessNeoadjuvant talazoparib in patients with germline BRCA1/2 mutation-positive, early-stage triple-negative breast cancer: exploration of tumor BRCA mutational status
Talazoparib monotherapy in patients with germline BRCA-mutated, early-stage triple-negative breast cancer (TNBC) showed activity in the neoadjuvant setting in the phase II NEOTALA study (NCT03499353). These bioma...
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Article
Open AccessGenomic analysis of advanced breast cancer tumors from talazoparib-treated gBRCA1/2mut carriers in the ABRAZO study
These analyses explore the impact of homologous recombination repair gene mutations, including BRCA1/2 mutations and homologous recombination deficiency (HRD), on the efficacy of the poly(ADP-ribose) polymerase (...
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Article
Open AccessA pan-cancer landscape of telomeric content shows that RAD21 and HGF alterations are associated with longer telomeres
Cancer cells can proliferate indefinitely through telomere maintenance mechanisms. These mechanisms include telomerase-dependent elongation, mediated by TERT activation, and alternative lengthening of telomeres (...
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Article
Open AccessPan-cancer analysis of the effect of biopsy site on tumor mutational burden observations
Tumor mutational burden (TMB) has been proposed as a predictive biomarker of response to immunotherapy. Efforts to standardize TMB scores for use in the clinic and to identify the factors that could impact TMB...
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Article
Open AccessUbiquitin fusion proteins in algae: implications for cell biology and the spread of photosynthesis
The process of gene fusion involves the formation of a single chimeric gene from multiple complete or partial gene sequences. Gene fusion is recognized as an important mechanism by which genes and their protei...
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Article
Open AccessMitochondrial mutations drive prostate cancer aggression
Nuclear mutations are well known to drive tumor incidence, aggression and response to therapy. By contrast, the frequency and roles of mutations in the maternally inherited mitochondrial genome are poorly unde...
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Article
Open AccessGermline BRCA2 mutations drive prostate cancers with distinct evolutionary trajectories
Germline mutations in the BRCA2 tumour suppressor are associated with both an increased lifetime risk of develo** prostate cancer (PCa) and increased risk of aggressive disease. To understand this aggression, h...
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Article
Genomic hallmarks of localized, non-indolent prostate cancer
Prostate tumours are highly variable in their response to therapies, but clinically available prognostic factors can explain only a fraction of this heterogeneity. Here we analysed 200 whole-genome sequences a...
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Article
Open AccessAlgal genomes reveal evolutionary mosaicism and the fate of nucleomorphs
Cryptophyte and chlorarachniophyte algae are transitional forms in the widespread secondary endosymbiotic acquisition of photosynthesis by engulfment of eukaryotic algae. Unlike most secondary plastid-bearing ...
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Plastid Evolution and the Nuclear Genomic “Footprint” of Red and Green Algal Endosymbionts
Plastids are the descendents of once free-living cyanobacterial endosymbionts and are generally believed to have evolved only once during eukaryotic evolution, in a common ancestor shared by red, green, and gl...
