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  1. Article

    Open Access

    Predictive value of p53, Ki67 and TLR5 in neoplastic progression of Barrett’s esophagus: a matched case–control study

    Barrett’s esophagus progresses to high-grade dysplasia or cancer along the well-established metaplasia-dysplasia-adenocarcinoma sequence. The aim of this study was to evaluate the value of p53, Ki67, and toll-...

    Olli Helminen, Jukka Melkko, Juha Saarnio, Eero Sihvo, Teijo Kuopio… in Virchows Archiv (2022)

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  2. Article

    Open Access

    Rheumatoid arthritis antigens homocitrulline and citrulline are generated by local myeloperoxidase and peptidyl arginine deiminases 2, 3 and 4 in rheumatoid nodule and synovial tissue

    Seropositive rheumatoid arthritis (RA) is characterized by autoantibodies binding to citrullinated and homocitrullinated proteins. We wanted to study the expression patterns of these disease-associated protein...

    Sanna Turunen, Johanna Huhtakangas, Tomi Nousiainen… in Arthritis Research & Therapy (2016)

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  3. Article

    Open Access

    Different amounts of protein-bound citrulline and homocitrulline in foot joint tissues of a patient with anti-citrullinated protein antibody positive erosive rheumatoid arthritis

    Antibodies binding to citrullinated proteins are a frequent finding in rheumatoid arthritis patients and may precede the onset of clinical symptoms several years. The antibodies are a predisposing factor for b...

    Sanna Turunen, Marja-Kaisa Koivula, Jukka Melkko… in Journal of Translational Medicine (2013)

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  4. No Access

    Article

    Serum is a rich source of ligands for the scavenger receptor of hepatic sinusoidal endothelial cells

    The present study was prompted by findings in our laboratory showing that serum effectively inhibits scavenger receptor (SR)-mediated endocytosis in hepatic sinusoidal endothelial cells (SEC). Experiments with...

    Berit Hansen, Jukka Melkko, Bård Smedsrød in Molecular and Cellular Biochemistry (2002)

  5. No Access

    Article

    Acetaldehyde Adducts in Blood and Bone Marrow of Patients With Ethanol-Induced Erythrocyte Abnormalities

    Although alcohol abuse is known to cause a wide array of adverse effects on blood cell formation, the molecular mechanisms by which alcohol exerts its toxic actions remain poorly defined. We examine here the f...

    Jaana Latvala, Seppo Parkkila, Jukka Melkko, Onni Niemelä MD in Molecular Medicine (2001)

  6. No Access

    Article

    Use of a marker of collagen formation in osteoporosis studies

    Type I collagen accounts for most of the organic matrix of bones, but it is also an important constituent of soft connective tissue. Assessment of the turnover of such collagen is particularly relevant to bone...

    Juha Risteli, Jukka Melkko, Seija Niemi, Leila Risteli in Calcified Tissue International (1991)