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Article
Genetic determinants of metabolic biomarkers and their associations with cardiometabolic traits in Hispanic/Latino adolescents
Metabolic regulation plays a significant role in energy homeostasis, and adolescence is a crucial life stage for the development of cardiometabolic disease (CMD). This study aims to investigate the genetic det...
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Article
Open AccessAPOC3 genetic variation, serum triglycerides, and risk of coronary artery disease in Asian Indians, Europeans, and other ethnic groups
Hypertriglyceridemia has emerged as a critical coronary artery disease (CAD) risk factor. Rare loss-of-function (LoF) variants in apolipoprotein C-III have been reported to reduce triglycerides (TG) and are ca...
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Article
Open AccessModeling methylation data as an additional genetic variance component
High-throughput platforms allow the characterization of thousands of previously known methylation sites. These platforms have great potential for investigating the epigenetic effects that are partially respons...
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Article
Open AccessProsaposin is a regulator of progranulin levels and oligomerization
Progranulin (GRN) loss-of-function mutations leading to progranulin protein (PGRN) haploinsufficiency are prevalent genetic causes of frontotemporal dementia. Reports also indicated PGRN-mediated neuroprotection ...
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Chapter and Conference Paper
Time Series Forecasting by Evolving Artificial Neural Networks Using “Shuffle”, Cross-Validation and Ensembles
Accurate time series forecasting are important for several business, research, and application of engineering systems. Evolutionary Neural Networks are particularly appealing because of their ability to design...
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Chapter
Design of Artificial Neural Networks Based on Genetic Algorithms to Forecast Time Series
In this work an initial approach to design Artificial Neural Networks to forecast time series is tackle, and the automatic process to design is carried out by a Genetic Algorithm. A key issue for these kinds o...
