15 Result(s)
within
Ju Han Kim
Science, Humanities and Social Sciences, multidisciplinary
English
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Article
Open AccessFactor-specific generative pattern from large-scale drug-induced gene expression profile
Drug discovery is a complex and interdisciplinary field that requires the identification of potential drug targets for specific diseases. In this study, we present FacPat, a novel approach that identifies the ...
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Article
Open AccessPrognosis after discontinuing renin angiotensin aldosterone system inhibitor for heart failure with restored ejection fraction after acute myocardial infarction
Prognostic effect of discontinuing renin–angiotensin–aldosterone-system-inhibitor (RAASi) for patients with heart failure (HF) after acute myocardial infarction (AMI) whose left ventricular (LV) systolic funct...
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Article
Open AccessAuthor Correction: Heterogeneous genetic landscape of congenital neutropenia in Korean patients revealed by whole exome sequencing: genetic, phenotypic and histologic correlations
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Article
Open AccessDeep learning model to predict Epstein–Barr virus associated gastric cancer in histology
The detection of Epstein–Barr virus (EBV) in gastric cancer patients is crucial for clinical decision making, as it is related with specific treatment responses and prognoses. Despite its importance, the limit...
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Article
Open AccessHeterogeneous genetic landscape of congenital neutropenia in Korean patients revealed by whole exome sequencing: genetic, phenotypic and histologic correlations
Congenital neutropenia (CN) is a hematological disease heterogeneous in its genetic, phenotypic and histologic aspects. We aimed to identify the genetic etiology of Korean CN patients in the context of bone ma...
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Open AccessPreliminary feasibility assessment of CDM-based active surveillance using current status of medical device data in medical records and OMOP-CDM
In recent years, there has been an emerging interest in the use of claims and electronic health record (EHR) data for evaluation of medical device safety and effectiveness. In Korea, national insurance electro...
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Article
Open AccessPaired comparisons of mutational profiles before and after brachytherapy in asian uveal melanoma patients
Uveal melanoma(UM) is the most common primary intraocular malignancy in adults. However, the incidence of UM in Asia is 10 to 20 times less than in Western populations. Therefore, for the first time, we report...
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Open AccessInterplay between IL6 and CRIM1 in thiopurine intolerance due to hematological toxicity in leukemic patients with wild-type NUDT15 and TPMT
NUDT15 and TPMT variants are strong genetic determinants of thiopurine-induced hematological toxicity. Despite the impact of homozygous CRIM1 on thiopurine toxicity, several patients with wild-type NUDT15, TPMT, ...
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Open AccessClassification of cervical neoplasms on colposcopic photography using deep learning
Colposcopy is widely used to detect cervical cancers, but experienced physicians who are needed for an accurate diagnosis are lacking in develo** countries. Artificial intelligence (AI) has been recently use...
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Open AccessThe major effects of health-related quality of life on 5-year survival prediction among lung cancer survivors: applications of machine learning
The primary goal of this study was to evaluate the major roles of health-related quality of life (HRQOL) in a 5-year lung cancer survival prediction model using machine learning techniques (MLTs). The predicti...
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Article
Open AccessSex differences in the genetic architecture of depression
The prevalence and clinical characteristics of depressive disorders differ between women and men; however, the genetic contribution to sex differences in depressive disorders has not been elucidated. To evalua...
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Article
Open AccessClinical Genome Data Model (cGDM) provides Interactive Clinical Decision Support for Precision Medicine
In light of recent developments in genomic technology and the rapid accumulation of genomic information, a major transition toward precision medicine is anticipated. However, the clinical applications of genom...
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Open AccessGene expression profiling of calcifications in breast cancer
We investigated the gene expression profiles of calcifications in breast cancer. Gene expression analysis of surgical specimen was performed using Affymetrix GeneChip® Human Gene 2.0 ST arrays in 168 breast ca...
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Article
Open AccessSmall molecule-based lineage switch of human adipose-derived stem cells into neural stem cells and functional GABAergic neurons
Cellular reprogramming using small molecules (SMs) without genetic modification provides a promising strategy for generating target cells for cell-based therapy. Human adipose-derived stem cells (hADSCs) are a...
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Article
Open AccessComparative analysis of metazoan chromatin organization
A large collection of new modENCODE and ENCODE genome-wide chromatin data sets from cell lines and developmental stages in worm, fly and human are analysed; this reveals many conserved features of chromatin or...
