-
Article
Open AccessExploring the tradeoff between data privacy and utility with a clinical data analysis use case
Securing adequate data privacy is critical for the productive utilization of data. De-identification, involving masking or replacing specific values in a dataset, could damage the dataset’s utility. However, f...
-
Article
Preliminary Investigation on Efficacy and Safety of Substance P-Coated Stent for Promoting Re-Endothelialization: A Porcine Coronary Artery Restenosis Model
Current polymer-based drug-eluting stents (DESs) have fundamental issues about inflammation and delayed re-endothelializaton of the vessel wall. Substance-P (SP), which plays an important role in inflammation ...
-
Article
Open AccessResistant hypertension: consensus document from the Korean society of hypertension
Although reports vary, the prevalence of true resistant hypertension and apparent treatment-resistant hypertension (aTRH) has been reported to be 10.3% and 14.7%, respectively. As there is a rapid increase in ...
-
Article
Open AccessStatement on chronotherapy for the treatment of hypertension: consensus document from the Korean society of hypertension
Nocturnal blood pressure (BP) has been shown to have a significant predictive value for cardiovascular disease. In some cases, it has a superior predictive value for future cardiovascular outcomes than daytime...
-
Article
Open AccessClinical and life style factors related to the nighttime blood pressure, nighttime dip** and their phenotypes in Korean hypertensive patients
Non-dip** or reverse dip** patterns are known to be associated with adverse cardiovascular prognosis among the general population and clinical cohort. Few large sized studies have explored factors includin...
-
Article
Development and Application of an Active Pharmacovigilance Framework Based on Electronic Healthcare Records from Multiple Centers in Korea
With the availability of retrospective pharmacovigilance data, the common data model (CDM) has been identified as an efficient approach towards anonymized multicenter analysis; however, the establishment of a ...
-
Article
Open AccessFactor-specific generative pattern from large-scale drug-induced gene expression profile
Drug discovery is a complex and interdisciplinary field that requires the identification of potential drug targets for specific diseases. In this study, we present FacPat, a novel approach that identifies the ...
-
Article
Preclinical Evaluation of an Everolimus-Eluting Bioresorbable Vascular Scaffold Via a Long-Term Rabbit Iliac Artery Model
Biodegradable poly (l-lactic acid) (PLLA), a bio safe polymer with a large elastic modulus, is widely used in biodegradable medical devices. However, because of its poor mechanical properties, a PLLA strut mus...
-
Article
Open AccessPrognosis after discontinuing renin angiotensin aldosterone system inhibitor for heart failure with restored ejection fraction after acute myocardial infarction
Prognostic effect of discontinuing renin–angiotensin–aldosterone-system-inhibitor (RAASi) for patients with heart failure (HF) after acute myocardial infarction (AMI) whose left ventricular (LV) systolic funct...
-
Article
Open AccessThe 2022 focused update of the 2018 Korean Hypertension Society Guidelines for the management of hypertension
Hypertension is the leading cause of death in human being, which shows high prevalence and associated complications that increase the mortality and morbidity. Controlling blood pressure (BP) is very important ...
-
Article
Open AccessAuthor Correction: Heterogeneous genetic landscape of congenital neutropenia in Korean patients revealed by whole exome sequencing: genetic, phenotypic and histologic correlations
-
Article
Open AccessDeep learning model to predict Epstein–Barr virus associated gastric cancer in histology
The detection of Epstein–Barr virus (EBV) in gastric cancer patients is crucial for clinical decision making, as it is related with specific treatment responses and prognoses. Despite its importance, the limit...
-
Article
Open AccessHome blood pressure monitoring: a position statement from the Korean Society of Hypertension Home Blood Pressure Forum
Home blood pressure measurement (HBPM) has the advantage of measuring blood pressure (BP) multiple times over a long period. HBPM effectively diagnoses stress-induced transient BP elevations (i.e., white coat ...
-
Article
Open AccessHeterogeneous genetic landscape of congenital neutropenia in Korean patients revealed by whole exome sequencing: genetic, phenotypic and histologic correlations
Congenital neutropenia (CN) is a hematological disease heterogeneous in its genetic, phenotypic and histologic aspects. We aimed to identify the genetic etiology of Korean CN patients in the context of bone ma...
-
Article
Open AccessDissection of molecular and histological subtypes of papillary thyroid cancer using alternative splicing profiles
Despite growing evidence of the relevance of alternative splicing (AS) to cancer development and progression, the biological implications of AS for tumor behaviors, including papillary thyroid cancer (PTC), re...
-
Article
Open AccessPreliminary feasibility assessment of CDM-based active surveillance using current status of medical device data in medical records and OMOP-CDM
In recent years, there has been an emerging interest in the use of claims and electronic health record (EHR) data for evaluation of medical device safety and effectiveness. In Korea, national insurance electro...
-
Article
Open AccessPaired comparisons of mutational profiles before and after brachytherapy in asian uveal melanoma patients
Uveal melanoma(UM) is the most common primary intraocular malignancy in adults. However, the incidence of UM in Asia is 10 to 20 times less than in Western populations. Therefore, for the first time, we report...
-
Article
Open AccessInterplay between IL6 and CRIM1 in thiopurine intolerance due to hematological toxicity in leukemic patients with wild-type NUDT15 and TPMT
NUDT15 and TPMT variants are strong genetic determinants of thiopurine-induced hematological toxicity. Despite the impact of homozygous CRIM1 on thiopurine toxicity, several patients with wild-type NUDT15, TPMT, ...
-
Article
Open AccessCaReAl: capturing read alignments in a BAM file rapidly and conveniently
Some of the variants detected by high-throughput sequencing (HTS) are often not reproducible. To minimize the technical-induced artifacts, secondary experimental validation is required but this step is unneces...
-
Article
Open AccessEffectiveness of antipsychotic drugs in schizophrenia: a 10-year retrospective study in a Korean tertiary hospital
Extensive research has been carried out on the comparative effectiveness of antipsychotic medications. Most studies, however, have been performed in Western countries. The purpose of this study was to compare ...
