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Article
Open AccessProstaglandin E2 controls the metabolic adaptation of T cells to the intestinal microenvironment
Immune cells must adapt to different environments during the course of an immune response. Here we study the adaptation of CD8+ T cells to the intestinal microenvironment and how this process shapes the establish...
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Article
Open AccessViral vector-mediated reprogramming of the fibroblastic tumor stroma sustains curative melanoma treatment
The tumor microenvironment (TME) is a complex amalgam of tumor cells, immune cells, endothelial cells and fibroblastic stromal cells (FSC). Cancer-associated fibroblasts are generally seen as tumor-promoting e...
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Article
Adenovirus vector vaccination reprograms pulmonary fibroblastic niches to support protective inflating memory CD8+ T cells
Pathogens and vaccines that produce persisting antigens can generate expanded pools of effector memory CD8+ T cells, described as memory inflation. While properties of inflating memory CD8+ T cells have been char...
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Article
Open AccessB cell zone reticular cell microenvironments shape CXCL13 gradient formation
Through the formation of concentration gradients, morphogens drive graded responses to extracellular signals, thereby fine-tuning cell behaviors in complex tissues. Here we show that the chemokine CXCL13 forms...
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Article
Fibroblastic reticular cells regulate intestinal inflammation via IL-15-mediated control of group 1 ILCs
Fibroblastic reticular cells influence the function of lymphocytes in secondary lymphoid organs. Ludewig and colleagues demonstrate that they also specifically restrain the activation of group 1 innate lymphoi...
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Article
Mathematical models for CFSE labelled lymphocyte dynamics: asymmetry and time-lag in division
Since their invention in 1994, fluorescent dyes such as carboxyfluorescein diacetate succinimidyl ester (CFSE) are used for cell proliferation analysis in flow cytometry. Importantly, the interpretation of suc...
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Article
B cell homeostasis and follicle confines are governed by fibroblastic reticular cells
Naive B and T cells exist in discrete zones in lymph nodes. Turley and colleagues demonstrate that a distinct subset of fibroblastic reticular cells reside in B cell zones, where they sustain B cell survival b...
