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Article
Open AccessEZH2 variants differentially regulate polycomb repressive complex 2 in histone methylation and cell differentiation
Polycomb repressive complex 2 (PRC2) is responsible for establishing and maintaining histone H3K27 methylation during cell differentiation and proliferation. H3K27 can be mono-, di-, or trimethylated, resultin...
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Article
Open AccessInteractome determination of a Long Noncoding RNA implicated in Embryonic Stem Cell Self-Renewal
Long noncoding RNAs (lncRNAs) constitute a significant fraction of mammalian transcriptomes and they have emerged as intricate regulators of many biological processes. Their broad capacity to adopt diverse str...
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Article
Open AccessSex bias in CNS autoimmune disease mediated by androgen control of autoimmune regulator
Male gender is protective against multiple sclerosis and other T-cell-mediated autoimmune diseases. This protection may be due, in part, to higher androgen levels in males. Androgen binds to the androgen recep...
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Article
Open AccessDetecting broad domains and narrow peaks in ChIP-seq data with hiddenDomains
Correctly identifying genomic regions enriched with histone modifications and transcription factors is key to understanding their regulatory and developmental roles. Conceptually, these regions are divided int...
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Article
Open AccessFastq2vcf: a concise and transparent pipeline for whole-exome sequencing data analyses
Whole-exome sequencing (WES) is a popular next-generation sequencing technology used by numerous laboratories with various levels of statistical and analytical expertise. Centralized databases, such as the Seq...
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Article
Coexistent ARID1A–PIK3CA mutations promote ovarian clear-cell tumorigenesis through pro-tumorigenic inflammatory cytokine signalling
Ovarian clear-cell carcinoma (OCCC) is an aggressive form of ovarian cancer with high ARID1A mutation rates. Here we present a mutant mouse model of OCCC. We find that ARID1A inactivation is not sufficient for tu...
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Article
Topoisomerases facilitate transcription of long genes linked to autism
Topoisomerases are expressed throughout the develo** and adult brain and are mutated in some individuals with autism spectrum disorder (ASD). However, how topoisomerases are mechanistically connected to ASD ...
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Article
Evidence of **st RNA-independent initiation of mouse imprinted X-chromosome inactivation
Female mammals carry two copies of the X chromosome, compared to the one X and one Y of the male, and to counter the potentially toxic effect of a double-dose of a gene, most of the genes on one X chromosome a...
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Article
Open AccessHuman population structure detection via multilocus genotype clustering
We describe a hierarchical clustering algorithm for using Single Nucleotide Polymorphism (SNP) genetic data to assign individuals to populations. The method does not assume Hardy-Weinberg equilibrium and linka...
