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  1. No Access

    Article

    Mycobacterial pseudotumor of the skin

    Inflammatory pseudotumors have a diverse etiology, mycobacterial pseudotumor (MP) being one of them. MP is a rare entity; it has been reported infrequently in various organs and is extremely rare in the skin. ...

    Mahboubeh Rahmani, Joseph Alroy, Driss Zoukhri, Richard O. Wein… in Virchows Archiv (2013)

  2. No Access

    Article

    Oncocytic adrenal cortical tumor with cytoplasmic inclusions and hyaline globules

    Adrenal cortical tumors, particularly oncocytic tumors, have been reported to contain a variety of intracytoplasmic and intramitochondrial inclusions. Oncocytic cortical tumors can also morphologically mimic p...

    Tariq Al-Zaid, Joseph Alroy, Rolf Pfannl, Katherine J. Strissel… in Virchows Archiv (2008)

  3. Article

    Open Access

    Imagable 4T1 model for the study of late stage breast cancer

    The 4T1 mouse mammary tumor cell line is one of only a few breast cancer models with the capacity to metastasize efficiently to sites affected in human breast cancer. Here we describe two 4T1 cell lines modifi...

    Kai Tao, Min Fang, Joseph Alroy, G Gary Sahagian in BMC Cancer (2008)

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  4. No Access

    Article

    Cardiotoxicity of the cancer therapeutic agent imatinib mesylate

    Imatinib mesylate (Gleevec) is a small-molecule inhibitor of the fusion protein Bcr-Abl, the causal agent in chronic myelogenous leukemia. Here we report ten individuals who developed severe congestive heart f...

    Risto Kerkelä, Luanda Grazette, Rinat Yacobi, Cezar Iliescu… in Nature Medicine (2006)

  5. No Access

    Article

    Caprine mucopolysaccharidosis IIID

    Mucopolysaccharidosis IIID (MPS IIID) is a lysosomal storage disease associated with deficient activity of the enzyme N-acetylglucosamine 6-sulfatase (EC 3.1.6.14), a lysosomal hydrolase in the heparan sulfate gl...

    Margaret Z. Jones, Joseph Alroy, Erinn Downs-Kelly… in Journal of Molecular Neuroscience (2004)

  6. No Access

    Article

    Caprine mucopolysaccharidosis IIID

    Mucopolysaccharidosis type IIID (MPS IIID) is a lysosomal storage disorder resulting from lack of activity of the lysosomal hydrolase N-acetylglucosamine 6-sulfatase (6S) (EC 3.1.6.14). The syndrome is associated...

    Erinn Downs-Kelly, Margaret Z. Jones, Joseph Alroy… in Journal of Molecular Neuroscience (2000)

  7. No Access

    Article

    Favorable effect of VEGF gene transfer on ischemic peripheral neuropathy

    Ischemic peripheral neuropathy is a frequent, irreversible complication of lower extremity vascular insufficiency. We investigated whether ischemic peripheral neuropathy could be prevented and/or reversed by g...

    Peter Schratzberger, Gabriele Schratzberger, Marcy Silver, Cynthia Curry… in Nature Medicine (2000)

  8. No Access

    Article

    Infantile GM1 Gangliosidosis: Complete Morphology and Histochemistry of Two Autopsy Cases, with Particular Reference to Delayed Central Nervous System Myelination

    Inborn metabolic errors causing lysosomal storage, such as β-galactosidase deficiency (GM1 gangliosidosis [GM1]), have well-recognized effects on cellular function and morphology. In some classically “neuronal” ...

    Rebecca D. Folkerth, Joseph Alroy, Ina Bhan… in Pediatric and Developmental Pathology (2000)

  9. No Access

    Article

    Chromosomal localization of two genes underlying late-infantile neuronal ceroid lipofuscinosis

    Classical late-infantile neuronal ceroid lipofuscinosis (LINCL;CLN2) is an inherited neurodegenerative disorder of childhood characterized by seizures, loss of vision, and progressive motor and mental deteriorat...

    J. L. Haines, Rose-Mary N. Boustany, Joseph Alroy, Kristen J. Auger… in Neurogenetics (1998)

  10. No Access

    Article

    An in vitro model for abnormal skeletal development in the lysosomal storage diseases

    Lysosomal storage diseases such as GM1-gangliosidosis are associated with skeletal abnormalities. Radiological and histological studies, both in human and corresponding animal models, indicate retarded bone forma...

    Amy Lyn Aulthouse, Joseph Alroy in Virchows Archiv (1995)

  11. No Access

    Article

    Ultrastructure of human dermal mast cells in 29 different lysosomal storage diseases

    The effect of lysosomal storage diseases on the ultrastructure of human mast cells has not previously been reported. Indeed, there has been little published evidence indicating that mast cells contain typical ...

    Ilan Hammel, Joseph Alroy, Vibha Goyal, Stephen J. Galli in Virchows Archiv B (1993)

  12. No Access

    Article

    Identification of a developmentally regulated sialidase inEimeria tenella that is immunologically related to theTrypanosoma cruzi enzyme

    Sporozoites and merozoites of three species ofEimeria, E. tenella, E. maxima, andE. necatrix, that cause diarrhea in chickens worldwide, were examined for their expression of sialidase (SA) activity. The enzyme w...

    Jean-Luc J. Pellegrin, Eduardo Ortega-Barria, Reginaldo P. Prioli… in Glycoconjugate Journal (1993)

  13. No Access

    Article

    Storage of glycoprotein in NCTR-Balb/C mouse

    A strain of Balb/C mice carrying a lysosomal storage disorder exhibits metabolic and phenotypic abnormalities similar to patients with sphingomyelin-cholesterol lipidoses type II (i.e., Niemann-Pick C and D). ...

    Hana Weintraub, Joseph Alroy, Rita DeGasperi, Vibha Goyal… in Virchows Archiv B (1992)

  14. No Access

    Article

    Adult onset lysosomal storage disease in a Tibetan terrier: Clinical, morphological and biochemical studies

    We describe a novel late-onset lysosomal lipid storage disease affecting a Tibetan terrier. The principal clinical manifestations include visual loss, progressive cerebellar ataxia and dementia. A necropsy of ...

    Joseph Alroy, Scott H. Schelling, Johann G. Thalhammer… in Acta Neuropathologica (1992)

  15. No Access

    Article

    Glycoconjugates of the intestinal epithelium of the domestic fowl (Gallus domesticus): A lectin histochemistry study

    A lectin histochemical study was performed on formalin-fixed paraffin-embedded tissues of duodenum, jejunum, ileum, caecum and colon from six fasted and six non-fasted 8-week-old chickens (Gallus domesticus). The...

    Joseph Alroy, Vibha Goyal, Nicholas W. Lukacs… in The Histochemical Journal (1989)

  16. No Access

    Chapter and Conference Paper

    Alpha-Mannosidase Deficiency in Persian Cats: A Model of Human Alpha-Mannosidosis

    A family of cats deficient in lysosomal α-mannosidase activity was studied. Analysis of the family pedigree indicated an autosomal recessive mode of inheritance. All affected kittens had frontal bossing, facia...

    Joseph Alroy, Kenneth L. Schunk, Srinivasa S. Ranghavan… in Lipid Storage Disorders (1988)

  17. No Access

    Article

    Lectin histochemistry and ultrastructure of feline kidneys from six different storage diseases

    We have compared the pattern of lectin staining with the ultrastructural features of kidneys from normal cats and 19 cats with 6 different lysosomal storage diseases. The diseases studied include GM1 and GM2 gang...

    Massimo Castagnaro, Joseph Alroy, Angelo A. Ucci, Robert H. Glew in Virchows Archiv B (1987)

  18. No Access

    Article

    Cell surface coat of human and rat bladder urothelium

    We have studied the ultrastructure of glycocalyx at the luminal surface of normal and diseased urothelium from humans and rats with ruthenium red staining. A correlation between the thickness and staining inte...

    Joseph Alroy, Vibha Goyal, Angelo A. Ucci… in Virchows Archiv B Cell Pathology Including… (1983)

  19. No Access

    Article

    Primary adenocarcinomas of the human urinary bladder: Histochemical, immunological and ultrastructural studies

    Neoplastic and non-neoplastic tissue specimens from ten patients with primary adenocarcinoma of the urinary bladder were examined. Most of these tumors were associated with either foci of transitional cell car...

    Joseph Alroy, Danica Roganovic, Barbara F. Banner, Jerome B. Jacobs… in Virchows Archiv A (1981)

  20. No Access

    Article

    Alterations of intercellular junctions in acinic cell carcinoma of the canine pancreas

    Intercellular junctions in spontaneous canine pancreatic acinic cell adenocarcinomas were compared to those in control canine pancreas. The neoplastic cells displayed proliferation and fragmentation of tight j...

    Joseph Alroy, Barbara F. Banner, Bendicht U. Pauli, Irwin Leav in Virchows Archiv B (1978)