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9 Result(s)

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  1. Article

    Open Access

    A conserved RNA structural motif for organizing topology within picornaviral internal ribosome entry sites

    Picornaviral IRES elements are essential for initiating the cap-independent viral translation. However, three-dimensional structures of these elements remain elusive. Here, we report a 2.84-Å resolution crysta...

    Deepak Koirala, Yaming Shao, Yelena Koldobskaya, James R. Fuller… in Nature Communications (2019)

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  2. Article

    Open Access

    Structural basis for activation of fluorogenic dyes by an RNA aptamer lacking a G-quadruplex motif

    The DIR2s RNA aptamer, a second-generation, in-vitro selected binder to dimethylindole red (DIR), activates the fluorescence of cyanine dyes, DIR and oxazole thiazole blue (OTB), allowing detection of two well...

    Sandip A. Shelke, Yaming Shao, Artur Laski, Deepak Koirala… in Nature Communications (2018)

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  3. Article

    Open Access

    Synthesizing topological structures containing RNA

    Though knotting and entanglement have been observed in DNA and proteins, their existence in RNA remains an enigma. Synthetic RNA topological structures are significant for understanding the physical and biolog...

    Di Liu, Yaming Shao, Gang Chen, Yuk-Ching Tse-Dinh… in Nature Communications (2017)

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  4. No Access

    Article

    RNA made in its own mirror image

    An RNA enzyme has been generated that can assemble a mirror-image version of itself. The finding helps to answer a long-standing conundrum about how RNA molecules could have proliferated on prebiotic Earth. See L...

    Sandip A. Shelke, Joseph A. Piccirilli in Nature (2014)

  5. No Access

    Article

    RNA catalyses nuclear pre-mRNA splicing

    In nuclear pre-messenger RNA splicing, introns are excised by the spliceosome, a dynamic machine composed of both proteins and small nuclear RNAs (snRNAs). Over thirty years ago, after the discovery of self-sp...

    Sebastian M. Fica, Nicole Tuttle, Thaddeus Novak, Nan-Sheng Li, Jun Lu… in Nature (2013)

  6. No Access

    Article

    Metal ion catalysis during splicing of premessenger RNA

    The removal of intervening sequences from premessenger RNA is essential for the expression of most eukaryotic genes. The spliceosome ribonucleoprotein complex catalyses intron removal by two sequential phospho...

    Erik J. Sontheimer, Sengen Sun, Joseph A. Piccirilli in Nature (1997)

  7. No Access

    Article

    RNA seeks its maker

    Joseph A. Piccirilli in Nature (1995)

  8. No Access

    Article

    Metal ion catalysis in the Tetrahymena ribozyme reaction

    ALL catalytic RNAs (ribozymes) require or are stimulated by divalent metal ions, but it has been difficult to separate the contribution of these metal ions to formation of the RNA tertiary structure1 from a more ...

    Joseph A. Piccirilli, Joseph S. Vyle, Marvin H. Caruthers, Thomas R. Cech in Nature (1993)

  9. No Access

    Article

    Enzymatic incorporation of a new base pair into DNA and RNA extends the genetic alphabet

    A new Watson-Crick base pair, with a hydrogen bonding pattern different from that in the A·T and G·C base pairs, is incorporated into duplex DNA and RNA by DNA and RNA polymerases and expands the genetic alpha...

    Joseph A. Piccirilli, Steven A. Benner, Tilman Krauch, Simon E. Moroney… in Nature (1990)