8 Result(s)
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Joon-Hyuk Lee
Science, Humanities and Social Sciences, multidisciplinary
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Article
Author Correction: Disease-associated astrocyte epigenetic memory promotes CNS pathology
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Article
Disease-associated astrocyte epigenetic memory promotes CNS pathology
Disease-associated astrocyte subsets contribute to the pathology of neurologic diseases, including multiple sclerosis and experimental autoimmune encephalomyelitis1–8 (EAE), an experimental model for multiple scl...
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Open AccessAuthor Correction: Stroke subtype-dependent synapse elimination by reactive gliosis in mice
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Open AccessStroke subtype-dependent synapse elimination by reactive gliosis in mice
The pathological role of reactive gliosis in CNS repair remains controversial. In this study, using murine ischemic and hemorrhagic stroke models, we demonstrated that microglia/macrophages and astrocytes are ...
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Astrocytes phagocytose adult hippocampal synapses for circuit homeostasis
In the adult hippocampus, synapses are constantly formed and eliminated1,2. However, the exact function of synapse elimination in the adult brain, and how it is regulated, are largely unknown. Here we show that a...
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Open AccessThe rostroventral part of the thalamic reticular nucleus modulates fear extinction
The thalamus has been implicated in fear extinction, yet the role of the thalamic reticular nucleus (TRN) in this process remains unclear. Here, in mice, we show that the rostroventral part of the TRN (TRNrv) ...
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Article
Human glioblastoma arises from subventricular zone cells with low-level driver mutations
Glioblastoma (GBM) is a devastating and incurable brain tumour, with a median overall survival of fifteen months1,2. Identifying the cell of origin that harbours mutations that drive GBM could provide a fundament...
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Open AccessLFP-guided targeting of a cortical barrel column for in vivo two-photon calcium imaging
Two-photon microscopy of bulk-loaded functional dyes is an outstanding physiological technique that enables simultaneous functional map** of hundreds of brain cells in vivo at single-cell resolution. However, p...
