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Article
Open AccessEvaluation of a Apo-1/Fas promoter polymorphism in Korean stroke patients
Apoptosis has been implicated in the pathogenesis of neurodegenerative diseases such as stroke and Alzheimer's disease. Apo-1/Fas gene is one of the mediators of apoptosis in stroke. MvaI polymorphism is the f...
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Article
Apolipoprotein E polymorphism and clinical course in childhood nephrotic syndrome
Numerous studies have reported on the role of apolipoprotein E (apoE) polymorphism in the progression of diseases associated with lipid abnormalities. However, few studies have been performed to date on the re...
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Article
Open AccessAngiotensin converting enzyme gene polymorphism in Korean patients with primary knee osteoarthritis
Angiotensin converting enzyme (ACE) plays an important role in the physiology of vasculature, blood pressure and inflammation. ACE gene, known to have insertion/deletion (I/D) polymorphism, has been widely inv...
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Article
Association of IL-1β, IL-1ra, and TNF-α gene polymorphisms in childhood nephrotic syndrome
We investigated the association between IL-1β, IL-1ra, and TNF-α gene polymorphisms and childhood nephrotic syndrome (NS). We analyzed the genetic polymorphism of IL-1β, IL-1ra, and TNF-α genes in 152 patients...
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Article
Estrogen receptor-α gene haplotype is associated with primary knee osteoarthritis in Korean population
Estrogen and estrogen receptors (ERs) are known to play important roles in the pathophysiology of osteoarthritis (OA). To investigate ER-α gene polymorphisms for its associations with primary knee OA, we condu...
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Article
Open AccessAssociation study of polymorphisms in synaptic vesicle-associated genes, SYN2 and CPLX2, with schizophrenia
The occurrence of aberrant functional connectivity in the neuronal circuit is one of the integrative theories of the etiology of schizophrenia. Previous studies have reported that the protein and mRNA levels o...
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Article
Promoter Polymorphism (rs3755724, -55C/T) of Tissue Inhibitor of Metalloproteinase 4 (TIMP4) as a Risk Factor for Kawasaki Disease with Coronary Artery Lesions in a Korean Population
Kawasaki disease (KD) is an acute febrile vasculitis that predominantly affects infants and young children. Tissue inhibitors of matrix metalloproteinases (TIMPs) comprise a family of four members, of which TI...
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Article
Involvement of tryptophan hydroxylase 2 (TPH2) gene polymorphisms in susceptibility to coronary artery lesions in Korean children with Kawasaki disease
Kawasaki disease (KD) is an acute vasculitis of childhood that predominantly affects the coronary arteries. We investigated single nucleotide polymorphisms (SNPs) of the tryptophan hydroxylase 2 (TPH2) gene as...
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Article
Radical scavenging activity and anti-obesity effects in 3T3-L1 preadipocyte differentiation of Ssuk (Artemisia princeps Pamp.) extract
Radical scavenging activity of ethanol extracts from ssuk (Artemisia princeps Pampan.) was determined by 2,2-diphenyl-1-pycryl-hydrazil (DPPH) and 2,2′-azinobis(3-ethylbenzthiazoline-6-sulphonic acid) (ABTS) meth...
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Article
Open AccessNo association between polymorphisms of WNT2and schizophrenia in a Korean population
Wingless-type MMTV integration site family member 2 (WNT2) has a potentially important role in neuronal development; however, there has yet to be an investigation into the association between single nucleotide...
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Article
Open AccessAssociation between polymorphisms of arachidonate 12-lipoxygenase (ALOX12) and schizophrenia in a Korean population
Arachidonic acid (AA), an essential polyunsaturated fatty acid, is one of the major components of neural membranes, which show an altered phospholipid composition in schizophrenia. Arachidonate 12-lipoxygenase (A...
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Article
Characterization of gene expression regulated by Panax ginseng in SH-SY5Y cells
To investigate the effects of Panax ginseng (PG) on SH-SY5Y human neuroblastoma cells, we profiled gene expressions of both normal and PG-treated groups using cDNA microarray. We performed 3-(4,5-dimethylthiazol-...
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Article
Association of Niemann-Pick disease, type C2 (NPC2) polymorphisms with obesity in Korean population
Cholesterol homeostasis is essential for functional integrity of lipid. Niemann-Pick disease, type C2 (NPC2) encodes a protein containing a lipid recognition domain. NPC2 is related to regulation of cholesterol a...
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Article
Association of CTLA4, CD28 and ICOS gene polymorphisms with clinicopathologic characteristics of childhood IgA nephropathy in Korean population
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Article
Association between toll-like receptor 10 (TLR10) gene polymorphisms and childhood IgA nephropathy
Toll-like receptors (TLRs) play an important role in the induction and regulation of the innate immune system and adaptive immune responses. TLR10 gene polymorphisms have been reported to be associated with a ran...
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Article
Coding Single-Nucleotide Polymorphisms of Interleukin-1 Gene Cluster Are Not Associated with Kawasaki Disease in the Korean Population
This study aimed to examine whether coding single-nucleotide polymorphisms (cSNPs) of the interleukin-1 gene cluster [interleukin-1-alpha (IL1α), IL1β, IL-1-receptor antagonist (IL1RN)] are genetic markers of ...
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Article
Notch Homolog 4 Polymorphism and Kawasaki Disease
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Article
Association of Polymorphism in the Promoter of the Melatonin Receptor 1A Gene with Schizophrenia and with Insomnia Symptoms in Schizophrenia Patients
Schizophrenia patients commonly have sleep disturbances. In this study, we investigated whether single nucleotide polymorphisms (SNPs) in the promoter region of the melatonin receptor genes (MTNR1A and MTNR1B)...
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Article
Effect of Acupuncture on Hypothalamic–Pituitary–Adrenal System in Maternal Separation Rats
The maternal separation (MS) animal model has been widely used to study early life stress and several psychiatric conditions such as depression and anxiety. In this study, we investigated the effect of acupunc...
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Article
Promoter polymorphisms of the HLA-G gene, but not the HLA-E and HLA-F genes, is associated with non-segmental vitiligo patients in the Korean population
The aim of this study was to determine whether or not promoter polymorphisms of the class I major histocompatibility complex (HLA-E, HLA-F, and HLA-G) are associated with susceptibility to vitiligo. To identif...
