6 Result(s)
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Article
Open AccessStrategies in anti-Mycobacterium tuberculosis drug discovery based on phenotypic screening
The rise of multi- and extensively drug-resistant Mycobacterium tuberculosis (M. tb) strains and co-infection with human immunodeficiency virus has escalated the need for new anti-M. tb drugs. Numerous challenges...
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Article
Improvement of the productivity of ecumicin, a novel anti-tuberculosis agent, from new Nonomuraea sp. MJM5123
Ecumicin is a novel anti-tuberculosis agent produced by Nonomuraea sp. MJM5123 as a new strain of actinomycetes. First, in order to increase the cell mass of Nonomuraea sp. MJM5123, we optimized the culture condi...
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Article
Phosphoprotein affinity purification identifies proteins involved in S-adenosyl-L-methionine-induced enhancement of antibiotic production in Streptomyces coelicolor
Streptomycetes are the major natural source of clinical antibiotics. The enhanced secondary metabolite production of many streptomycetes by S-adenosylmethionine (SAM) in previous studies suggested the existence o...
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Article
Open AccessRegulation of Polar Peptidoglycan Biosynthesis by Wag31 Phosphorylation in Mycobacteria
Sensing and responding to environmental changes is a central aspect of cell division regulation. Mycobacterium tuberculosis contains eleven Ser/Thr kinases, two of which, PknA and PknB, are key signaling molecule...
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Article
Talosins A and B: New Isoflavonol Glycosides with Potent Antifungal Activity from Kitasatospora kifunensis MJM341
In our screening program for new antifungal agents from microbial secondary metabolites, we isolated two new isoflavonol glycosides, genistein 7-α-L-6-deoxy-talopyranoside (talosin A) and genistein 4′,7-di-α-L-6-...
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Article
Talosins A and B: New Isoflavonol Glycosides with Potent Antifungal Activity from Kitasatospora kifunensis MJM341
In our screening program for new antifungal agents from microbial secondary metabolites, two new isoflavonol glycosides with potent antifungal activity, talosins A and B, were isolated from the culture broth of K...
