8 Result(s)
within
Joo Hyun Nam
Neurosciences
Receptors
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Article
Bicarbonate permeation through anion channels: its role in health and disease
Many anion channels, frequently referred as Cl− channels, are permeable to different anions in addition to Cl−. As the second-most abundant anion in the human body, HCO3− permeation via anion channels has many im...
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Article
Identification of critical amino acids in the proximal C-terminal of TREK-2 K+ channel for activation by acidic pHi and ATP-dependent inhibition
TWIK-related two-pore domain K+ channels (TREKs) are regulated by intracellular pH (pHi) and Phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2). Previously, Glu306 in proximal C-terminal (pCt) of mouse TREK-1 was ...
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Article
Inhibition of TREK-2 K+ channels by PI(4,5)P2: an intrinsic mode of regulation by intracellular ATP via phosphatidylinositol kinase
TWIK-related two-pore domain K+ channels 1 and 2 (TREKs) are activated under various physicochemical conditions. However, the directions in which they are regulated by PI(4,5)P2 and intracellular ATP are not clea...
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Article
Selective serotonin reuptake inhibitors facilitate ANO6 (TMEM16F) current activation and phosphatidylserine exposure
Anoctamin 6 (ANO6) is a member of the recently identified TMEM16/anoctamin protein family comprising Ca2+-activated Cl− channels that generate outward-rectifying ionic currents in response to intracellular Ca2+ i...
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Article
Arachidonic acid-induced activation of large-conductance potassium channels and membrane hyperpolarization in mouse B cells
Lymphocytes express voltage-gated (Kv) and Ca2+-activated (IKCa1) K+ channels. Recently, we found that WEHI-231, an immature B cell line, expresses voltage-independent K+ channels called large-conductance backgro...
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Article
Facilitation of Ca2+-activated K+ channels (IKCa1) by mibefradil in B lymphocytes
K+ channels play critical roles in the proliferation and activation of lymphocytes. Mouse B cells express large-conductance background K+ channel (LKbg) in addition to the voltage-gated K+ channel (Kv) and Ca2+-a...
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Article
Voltage-dependent slowly activating anion current regulated by temperature and extracellular pH in mouse B cells
Voltage-dependent, outwardly rectifying anion channels have been described in various cells including lymphocytes. In this study, we found that murine B cells express the voltage-dependent slowly activating an...
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Article
Ca2+ influx through the basolateral- and luminal membranes of colonic epithelium in neonatal rats
In this study, the short-circuit currents (I sc) of electrolyte absorption and secretion in neonatal and adult rat colonic mucosa were compared and the role of Ca2+ influx through luminal ...
