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Open AccessImpact of insertion into the left internal jugular vein in chemoport-associated infections: a retrospective single-center study of 1690 cases
We analyzed chemoport insertion procedures to evaluate infectious morbidity and factors causing infection. This single-center retrospective study included 1690 cases of chemoport implantation between January 2...
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Article
Open AccessDysbiotic change in gastric microbiome and its functional implication in gastric carcinogenesis
Although there is a growing interest in the role of gastric microbiome on the development of gastric cancer, the exact mechanism is largely unknown. We aimed to investigate the changes of gastric microbiome du...
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Article
Open AccessDifference in spectral power density of sleep electroencephalography between individuals without insomnia and frequent hypnotic users with insomnia complaints
Previous spectral analysis studies on insomnia have shown inconsistent results due to their heterogeneity and small sample sizes. We compared the difference of electroencephalogram (EEG) spectral power during ...
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Article
Open AccessInsomnia subtypes characterised by objective sleep duration and NREM spectral power and the effect of acute sleep restriction: an exploratory analysis
Insomnia disorder (ID) is a heterogeneous disorder with proposed subtypes based on objective sleep duration. We speculated that insomnia subty** with additional power spectral analysis and measurement of res...
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Open AccessAndrogen-deprivation therapy and the risk of newly developed fractures in patients with prostate cancer: a nationwide cohort study in Korea
We evaluated the risk of osteoporosis and fractures associated with androgen deprivation therapy (ADT) use and duration in men with prostate cancer. From the nationwide claims database in South Korea, a total ...
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Open AccessWhole-genome sequencing reveals KRTAP1-1 as a novel genetic variant associated with antidepressant treatment outcomes
Achieving remission following initial antidepressant therapy in patients with major depressive disorder (MDD) is an important clinical result. Making predictions based on genetic markers holds promise for impr...
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Article
Open AccessA least action principle for interceptive walking
The principle of least effort has been widely used to explain phenomena related to human behavior ranging from topics in language to those in social systems. It has precedence in the principle of least action ...
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Open AccessLoss of skeletal muscle mass during palliative chemotherapy is a poor prognostic factor in patients with advanced gastric cancer
Cancer causes muscle mass loss, which is associated with a poor prognosis. Chemotherapy may also reduce muscle mass. We investigated skeletal muscle mass change during palliative chemotherapy for advanced gast...
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Open AccessDistribution and clinical impact of apolipoprotein E4 in subjective memory impairment and early mild cognitive impairment
The apolipoprotein E (APOE) e4 allele is the most common genetic variant associated with Alzheimer’s disease (AD). We sought to investigate the distribution of APOE genotypes across the full clinical AD spectr...
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Article
Open AccessProteomic Analysis of Host Cell Protein Dynamics in the Culture Supernatants of Antibody-Producing CHO Cells
Chinese hamster ovary (CHO) cells are the most common cell line used for the production of therapeutic proteins including monoclonal antibodies (mAbs). Host cell proteins (HCPs), secreted and released from lys...