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Article
Open AccessLong-term oncologic outcomes of unselected triple-negative breast cancer patients according to BRCA1/2 mutations
Triple-negative breast cancer (TNBC) patients are more likely to have BRCA1/2 mutations, with a prevalence rate of about 10–20%. Although several studies have analyzed the oncologic outcomes between BRCA1/2 carri...
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Article
Open AccessImpact of insertion into the left internal jugular vein in chemoport-associated infections: a retrospective single-center study of 1690 cases
We analyzed chemoport insertion procedures to evaluate infectious morbidity and factors causing infection. This single-center retrospective study included 1690 cases of chemoport implantation between January 2...
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Article
In vitro evidence of synergistic efficacy with asciminib combined with reduced dose of ATP-binding pocket tyrosine kinase inhibitors according to the ABL1 kinase domain mutation profile
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Article
Heat transfer and friction correlations for offset strip fins relative to the offset ratio
Previous studies on the dimensionless Fanning friction factor (f) and Colburn heat transfer factor (j) of offset strip fins have considered an offset ratios of 50. However, most mass-produced offset strip fins ha...
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Article
Effects of maternal cigarette smoke exposure on the progression of nonalcoholic steatohepatitis in offspring mice
Cigarette smoke (CS) is a dominant carcinogenic agent in a variety of human cancers. CS exposure during pregnancy can adversely affect the fetus. Non-alcoholic fatty liver disease (NAFLD) is considered as a he...
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Article
Open AccessDysbiotic change in gastric microbiome and its functional implication in gastric carcinogenesis
Although there is a growing interest in the role of gastric microbiome on the development of gastric cancer, the exact mechanism is largely unknown. We aimed to investigate the changes of gastric microbiome du...
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Article
Open AccessDifference in spectral power density of sleep electroencephalography between individuals without insomnia and frequent hypnotic users with insomnia complaints
Previous spectral analysis studies on insomnia have shown inconsistent results due to their heterogeneity and small sample sizes. We compared the difference of electroencephalogram (EEG) spectral power during ...
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Article
Open AccessInsomnia subtypes characterised by objective sleep duration and NREM spectral power and the effect of acute sleep restriction: an exploratory analysis
Insomnia disorder (ID) is a heterogeneous disorder with proposed subtypes based on objective sleep duration. We speculated that insomnia subty** with additional power spectral analysis and measurement of res...
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Article
Spatiotemporal behaviors of the ridership of a public transportation system during an epidemic outbreak: case of MERS in Seoul
During May and June 2015, an outbreak of the Middle East respiratory syndrome (MERS) occurred in Korea, which raised the fear of contagion throughout society and suppressed the use of public transportation sys...
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Article
Dietary supplementation with Ceriporia lacerata improves learning and memory in a scopolamine-induced amnesia mouse model
Ceriporia lacerata (CL) is a species of white rot fungi. In this study, we have examined the beneficial effect of CL on scopolamine-induced memory impairment in mice. A freeze-dried CL mycelial culture broth was ...
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Article
Open AccessNovel Alzheimer’s disease risk variants identified based on whole-genome sequencing of APOE ε4 carriers
Alzheimer’s disease (AD) is a progressive neurodegenerative disease associated with a complex genetic etiology. Besides the apolipoprotein E ε4 (APOE ε4) allele, a few dozen other genetic loci associated with AD ...
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Article
Open AccessAndrogen-deprivation therapy and the risk of newly developed fractures in patients with prostate cancer: a nationwide cohort study in Korea
We evaluated the risk of osteoporosis and fractures associated with androgen deprivation therapy (ADT) use and duration in men with prostate cancer. From the nationwide claims database in South Korea, a total ...
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Article
Does androgen-deprivation therapy increase the risk of ischemic cardiovascular and cerebrovascular diseases in patients with prostate cancer? A nationwide population-based cohort study
We investigated whether ADT use was associated with the risk of ischemic cardiovascular diseases (CVD) and cerebrovascular diseases (CrVD) in a nationwide population-based cohort.
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Article
Seasonal variations in overactive bladder drug prescription rates in women: a nationwide population-based study
Colder seasons can aggravate lower urinary tract symptoms, especially an overactive bladder (OAB). This aspect has been extensively studied in men and rarely in women. We investigated whether colder seasons in...
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Article
Comparison of surgical outcomes among different methods of esophagojejunostomy in laparoscopic total gastrectomy for clinical stage I proximal gastric cancer: results of a single-arm multicenter phase II clinical trial in Korea, KLASS 03
Laparoscopic distal gastrectomy for early gastric cancer has been widely accepted, but laparoscopic total gastrectomy has still not gained popularity because of technical difficulty and unsolved safety issue....
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Article
Open AccessWhole-genome sequencing reveals KRTAP1-1 as a novel genetic variant associated with antidepressant treatment outcomes
Achieving remission following initial antidepressant therapy in patients with major depressive disorder (MDD) is an important clinical result. Making predictions based on genetic markers holds promise for impr...
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Article
Open AccessA least action principle for interceptive walking
The principle of least effort has been widely used to explain phenomena related to human behavior ranging from topics in language to those in social systems. It has precedence in the principle of least action ...
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Article
Open AccessLoss of skeletal muscle mass during palliative chemotherapy is a poor prognostic factor in patients with advanced gastric cancer
Cancer causes muscle mass loss, which is associated with a poor prognosis. Chemotherapy may also reduce muscle mass. We investigated skeletal muscle mass change during palliative chemotherapy for advanced gast...
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Article
Open AccessDistribution and clinical impact of apolipoprotein E4 in subjective memory impairment and early mild cognitive impairment
The apolipoprotein E (APOE) e4 allele is the most common genetic variant associated with Alzheimer’s disease (AD). We sought to investigate the distribution of APOE genotypes across the full clinical AD spectr...
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Article
Alpine Vegetation on the Paekdu-San (Changbaishan) Summit of the North-east China
We aim to provide a syntaxonomical scheme for the alpine tundra vegetation of volcano Mount Paekdu (Changbaishan) bordering China and North Korea. From the field investigations in 1991, 2004, and 2009 a total ...
