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Article
Open AccessImpaired neuronal activity as a potential factor contributing to the underdeveloped cerebrovasculature in a young Parkinson’s disease mouse model
Misfolding of α-synuclein (α-Syn) in the brain causes cellular dysfunction, leading to cell death in a group of neurons, and consequently causes the progression of Parkinson’s disease (PD). Although many studi...
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Article
Open AccessSchizophrenia-associated Mitotic Arrest Deficient-1 (MAD1) regulates the polarity of migrating neurons in the develo** neocortex
Although large-scale genome-wide association studies (GWAS) have identified an association between MAD1L1 (Mitotic Arrest Deficient-1 Like 1) and the pathology of schizophrenia, the molecular mechanisms underlyin...
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Article
Open AccessHypoxia with inflammation and reperfusion alters membrane resistance by dynamically regulating voltage-gated potassium channels in hippocampal CA1 neurons
Hypoxia typically accompanies acute inflammatory responses in patients and animal models. However, a limited number of studies have examined the effect of hypoxia in combination with inflammation (Hypo-Inf) on...
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Article
Open AccessClozapine generates obsessive compulsive disorder-like behavior in mice
Clozapine is thought to induce obsessive compulsive symptoms (OCS) in schizophrenic patients. However, because OCS are often comorbid with schizophrenia regardless of clozapine treatment, it remains unclear wh...
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Article
Open AccessFrequency-dependent gating of feedforward inhibition in thalamofrontal synapses
Thalamic recruitment of feedforward inhibition is known to enhance the fidelity of the receptive field by limiting the temporal window during which cortical neurons integrate excitatory inputs. Feedforward inh...
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Article
Extrasynaptic homomeric glycine receptors in neurons of the rat trigeminal mesencephalic nucleus
The neurons in the trigeminal mesencephalic nucleus (Vmes) innervate jaw-closing muscle spindles and periodontal ligaments, and play a crucial role in the regulation of jaw movements. Recently, it was shown th...
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Article
Vesicular glutamate transporter 1 (VGLUT1)- and VGLUT2-immunopositive axon terminals on the rat jaw-closing and jaw-opening motoneurons
To provide information on the glutamatergic synapses on the trigeminal motoneurons, which may be important for understanding the mechanism of control of jaw movements, we investigated the distribution of vesic...
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Article
Expression of glycine receptor alpha 3 in the rat trigeminal neurons and central boutons in the brainstem
Increasing evidence shows that the homomeric glycine receptor is expressed in axon terminals and is involved in the presynaptic modulation of transmitter release. However, little is known about the expression ...
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Chapter
Toxicity of App Fragments
Alzheimer’s disease (AD) is a neurodegenerative disorder with progressive decline of cognitive function. The characteristic pathological features of the postmortem brain of AD patients include, among other fea...
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Chapter and Conference Paper
Etiological roles of A β and carboxyl terminal peptide fragments of amyloid precursor protein in Alzheimer disease
Alzheimer’s disease (AD) is a neurodegenerative disorder of the brain characterized by the presence of neuritic amyloid plaques and neurofibrillary tangles in various areas of the brain [1]. Many lines of evid...
