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Article
ETV6 dependency in Ewing sarcoma by antagonism of EWS-FLI1-mediated enhancer activation
The EWS-FLI1 fusion oncoprotein deregulates transcription to initiate the paediatric cancer Ewing sarcoma. Here we used a domain-focused CRISPR screen to implicate the transcriptional repressor ETV6 as a uniqu...
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Article
OCA-T1 and OCA-T2 are coactivators of POU2F3 in the tuft cell lineage
Tuft cells are a rare chemosensory lineage that coordinates immune and neural responses to foreign pathogens in mucosal tissues1. Recent studies have also revealed tuft-cell-like human tumours2,3, particularly as...
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Article
Open AccessDecoding the 5′ nucleotide bias of PIWI-interacting RNAs
PIWI-interacting RNAs (piRNAs) are at the center of a small RNA-based immune system that defends genomes against the deleterious action of mobile genetic elements (transposons). PiRNAs are highly variable in s...
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Article
From guide to target: molecular insights into eukaryotic RNA-interference machinery
RNA interference (RNAi) is a process by which small noncoding RNAs direct molecular machinery to silence gene expression. In this Review, Ipsaro and Joshua-Tor discuss the mechanisms and structures that govern...
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Article
The structural biochemistry of Zucchini implicates it as a nuclease in piRNA biogenesis
piRNAs act to protect the genome from the damaging effect of unrestrained expression of mobile elements; here it is suggested that the phosphodiesterase Zucchini may be the nuclease that generates the 5′ ends ...
