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Jonathan Hasselmann
Neurology
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Article
Open AccessPlaque-associated human microglia accumulate lipid droplets in a chimeric model of Alzheimer’s disease
Disease-associated microglia (DAMs), that surround beta-amyloid plaques, represent a transcriptionally-distinct microglial profile in Alzheimer’s disease (AD). Activation of DAMs is dependent on triggering rec...
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Article
Open AccessDevelopment and validation of a simplified method to generate human microglia from pluripotent stem cells
Microglia, the principle immune cells of the brain, play important roles in neuronal development, homeostatic function and neurodegenerative disease. Recent genetic studies have further highlighted the importa...
