3 Result(s)

Article

Author Correction: Gene expression and functional deficits underlie TREM2-knockout microglia responses in human models of Alzheimer’s disease

Amanda McQuade, You Jung Kang, Jonathan Hasselmann, Amit Jairaman… in Nature Communications (2023)

Article

Gene expression and functional deficits underlie TREM2-knockout microglia responses in human models of Alzheimer’s disease

The discovery of TREM2 as a myeloid-specific Alzheimer’s disease (AD) risk gene has accelerated research into the role of microglia in AD. While TREM2 mouse models have provided critical insight, the normal an...

Amanda McQuade, You Jung Kang, Jonathan Hasselmann, Amit Jairaman… in Nature Communications (2020)

Article

Development and validation of a simplified method to generate human microglia from pluripotent stem cells

Microglia, the principle immune cells of the brain, play important roles in neuronal development, homeostatic function and neurodegenerative disease. Recent genetic studies have further highlighted the importa...

Amanda McQuade, Morgan Coburn, Christina H. Tu… in Molecular Neurodegeneration (2018)