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Article
Open AccessCentrosome amplification and aneuploidy driven by the HIV-1-induced Vpr•VprBP•Plk4 complex in CD4+ T cells
HIV-1 infection elevates the risk of develo** various cancers, including T-cell lymphoma. Whether HIV-1-encoded proteins directly contribute to oncogenesis remains unknown. We observe that approximately 1–5%...
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Article
Glucocorticoids in T cell development, differentiation and function
Glucocorticoids (GCs) are small lipid hormones produced by the adrenals that maintain organismal homeostasis. Circadian and stress-induced changes in systemic GC levels regulate metabolism, cardiovascular and ...
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Article
Recruitment of calcineurin to the TCR positively regulates T cell activation
The phosphatase calcineurin targets NFAT transcription factors in T cells. Ashwell and colleagues show that calcineurin is recruited to the TCR signaling complex, where it reverses the inhibitory phosphorylati...
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Article
Selective inhibition of the p38 alternative activation pathway in infiltrating T cells inhibits pancreatic cancer progression
Blocking alternative activation of p38 in tumor-infiltrating CD4+ T cells reduces proinflammatory cytokine production and inhibits pancreatic cancer growth in mice.
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Article
Identification and characterization of polyclonal αβ-T cells with dendritic cell properties
An efficient immune response requires coordination between innate and adaptive immunity, which act through cells different in origin and function. Here we report the identification of thymus-derived αβ-T-cell ...
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Article
T cell priming: let there be light
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Article
The many paths to p38 mitogen-activated protein kinase activation in the immune system
Three p38 mitogen-activated protein kinase (MAPK)-family members (p38α, p38β and p38δ) are expressed by immune and inflammatory cells, and are activated by ext...
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Article
Correction: Corrigendum
In the letter by Wu et al. (Nature Cell Biol. 8, 398–406; 2006), the title was incorrect and should read as follows: Sensing of Lys 63-linked polyubiquitination by NEMO is a key event in NF-κB activation In th...
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Article
Sensing of Lys 63-linked polyubiquitination by NEMO is a key event in NF-κB activation
The transcription factor NF-κB is sequestered in the cytoplasm in a complex with IκB1. Almost all NF-κB activation pathways converge on IκB kinase (IKK), which phosphorylates IκB resulting in Lys 48-linked polyub...
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Article
The autoimmune suppressor Gadd45α inhibits the T cell alternative p38 activation pathway
The p38 MAP kinase (MAPK) is phosphorylated and activated by upstream MAPK kinases. T cells have an alternative pathway in which T cell receptor–activated tyrosine kinase Zap70 phosphorylates p38 on Tyr323. Mi...
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Article
Alternative p38 activation pathway mediated by T cell receptor–proximal tyrosine kinases
Signaling-responsive MAP kinases (MAPKs) are key in mediating immune responses and are activated through the phosphorylation of a Thr-X-Tyr motif by upstream MAPK kinases. Here we show that T cells stimulated ...
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Article
TNF-RII and c-IAP1 mediate ubiquitination and degradation of TRAF2
Tumour necrosis factor-α (TNF-α) is a proinflammatory mediator that exerts its biological functions by binding two TNF receptors (TNF-RI and TNF-RII), which initiate biological responses by interacting with ad...
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Article
Thymocyte Apoptosis
Apoptosis is the fate of most thymocytes. Many molecules participate in the decision of whether a thymocyte is to live or to die, including cell surface receptors, such as the T cell receptor for antigen, Notc...
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Article
Genomic instability in Gadd45a-deficient mice
Gadd45a-null mice generated by gene targeting exhibited several of the phenotypes characteristic of p53-deficient mice, including genomic instability, increased radiation carcinogenesis and a low frequency of exe...
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Article
Bacterial death induced by expression of the intracellular portion of human Fas
In attempting to produce the intracellular portion of human Fas (IC175–319) as a GST-fusion protein we found that expression of GST-IC175–319, but not GST alone or GST-IC231–298 (containing the Fas death domain),...
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Article
When complex worlds collide: retinoic acid and apoptosis
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Chapter
Nuclear Receptors and Thymocyte Apoptosis: Sha** the Immune Repertoire
Programmed cell death (PCD) plays a critical role in the generation of the antigen-specific immune repertoire. Both the T cell receptor (TCR) ligand-binding chains and immunoglobulin are generated randomly fro...
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Article
Dissociation of phosphoinositide hydrolysis and Ca2+ fluxes from the biological responses of a T-cell hybridoma
T lymphocytes can be activated in a variety of ways, including occupancy of the T cell antigen receptor (TCR) complex or cross-linking of certain cell-surface molecules with antibody1–4. Two of the earliest event...
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Article
T-cell recognition of antigen and the Ia molecule as a ternary complex
T-Iymphocyte co-recognition of antigen and major histocompati-bility complex (MHC)-encoded molecules (such as murine Ia molecules) is thought to be mediated by a single cell-surface receptor, although the mole...
