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Article
Open AccessARL15 modulates magnesium homeostasis through N-glycosylation of CNNMs
Cyclin M (CNNM1-4) proteins maintain cellular and body magnesium (Mg2+) homeostasis. Using various biochemical approaches, we have identified members of the CNNM family as direct interacting partners of ADP-ribos...
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Article
Open AccessAXL confers cell migration and invasion by hijacking a PEAK1-regulated focal adhesion protein network
Aberrant expression of receptor tyrosine kinase AXL is linked to metastasis. AXL can be activated by its ligand GAS6 or by other kinases, but the signaling pathways conferring its metastatic activity are unkno...
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Article
Author Correction: Map** the proximity interaction network of the Rho-family GTPases reveals signalling pathways and regulatory mechanisms
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Article
Map** the proximity interaction network of the Rho-family GTPases reveals signalling pathways and regulatory mechanisms
Guanine nucleotide exchange factors (RhoGEFs) and GTPase-activating proteins (RhoGAPs) coordinate the activation state of the Rho family of GTPases for binding to effectors. Here, we exploited proximity-depend...
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Article
Natural selection contributed to immunological differences between hunter-gatherers and agriculturalists
The shift from a hunter-gatherer to an agricultural mode of subsistence is believed to have been associated with profound changes in the burden and diversity of pathogens across human populations. Yet, the ext...
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Article
Open AccessGFI1 facilitates efficient DNA repair by regulating PRMT1 dependent methylation of MRE11 and 53BP1
GFI1 is a transcriptional regulator expressed in lymphoid cells, and an “oncorequisite” factor required for development and maintenance of T-lymphoid leukemia. GFI1 deletion causes hypersensitivity to ionizing...
