9 Result(s)

Article

Loss of Y in regulatory T lymphocytes in the tumor micro-environment of primary colorectal cancers and liver metastases

Male sex is a risk factor for colorectal cancer (CRC) with higher illness burden and earlier onset. Thus, we hypothesized that loss of chromosome Y (LOY) in the tumor micro-environment (TME) might be involved ...

Magdalena Wójcik, Ulana Juhas, Elyas Mohammadi, Jonas Mattisson… in Scientific Reports (2024)

Article

Loss of chromosome Y in regulatory T cells

Mosaic loss of chromosome Y (LOY) in leukocytes is the most prevalent somatic aneuploidy in aging humans. Men with LOY have increased risks of all-cause mortality and the major causes of death, including many ...

Jonas Mattisson, Jonatan Halvardson, Hanna Davies, Bożena Bruhn-Olszewska… in BMC Genomics (2024)

Article

Loss of Y and clonal hematopoiesis in blood—two sides of the same coin?

Viktor Ljungström, Jonas Mattisson, Jonatan Halvardson, Tatjana Pandzic… in Leukemia (2022)

Article

A polygenic risk score predicts mosaic loss of chromosome Y in circulating blood cells

Mosaic loss of Y chromosome (LOY) is the most common somatic change that occurs in circulating white blood cells of older men. LOY in leukocytes is associated with increased risk for all-cause mortality and a ...

Moeen Riaz, Jonas Mattisson, Galina Polekhina, Andrew Bakshi… in Cell & Bioscience (2021)

Article

Leukocytes with chromosome Y loss have reduced abundance of the cell surface immunoprotein CD99

Mosaic loss of chromosome Y (LOY) in immune cells is a male-specific mutation associated with increased risk for morbidity and mortality. The CD99 gene, positioned in the pseudoautosomal regions of chromosomes X ...

Jonas Mattisson, Marcus Danielsson, Maria Hammond, Hanna Davies… in Scientific Reports (2021)

Article

Immune cells lacking Y chromosome show dysregulation of autosomal gene expression

Epidemiological investigations show that mosaic loss of chromosome Y (LOY) in leukocytes is associated with earlier mortality and morbidity from many diseases in men. LOY is the most common acquired mutation a...

Jan P. Dumanski, Jonatan Halvardson, Hanna Davies… in Cellular and Molecular Life Sciences (2021)

Article

Whole genome sequencing of familial isolated oesophagus atresia uncover shared structural variants

Oesophageal atresia (OA) is a life-threatening developmental defect characterized by a lost continuity between the upper and lower oesophagus. The most common form is a distal connection between the trachea an...

Joakim Klar, Helene Engstrand-Lilja, Khurram Maqbool… in BMC Medical Genomics (2020)