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  1. No Access

    Article

    The amino acid transporter SLC7A5 is required for efficient growth of KRAS-mutant colorectal cancer

    Oncogenic KRAS mutations and inactivation of the APC tumor suppressor co-occur in colorectal cancer (CRC). Despite efforts to target mutant KRAS directly, most therapeutic approaches focus on downstream pathways,...

    Arafath K. Najumudeen, Fatih Ceteci, Sigrid K. Fey, Gregory Hamm… in Nature Genetics (2021)

  2. Article

    Open Access

    Brf1 loss and not overexpression disrupts tissues homeostasis in the intestine, liver and pancreas

    RNA polymerase III (Pol-III) transcribes tRNAs and other small RNAs essential for protein synthesis and cell growth. Pol-III is deregulated during carcinogenesis; however, its role in vivo has not been studied...

    Dritan Liko, Louise Mitchell, Kirsteen J. Campbell… in Cell Death & Differentiation (2019)

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    Article

    mTORC1-mediated translational elongation limits intestinal tumour initiation and growth

    The mTORC1 complex has been implicated in tumorigenesis owing partially to its ability to increase protein translation; now, mTORC1 activity in the mouse intestine is shown not to be required for normal homeos...

    William J. Faller, Thomas J. Jackson, John R. P. Knight, Rachel A. Ridgway… in Nature (2015)