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Article
Comparison of Immersed Boundary Simulations of Heart Valve Hemodynamics Against In Vitro 4D Flow MRI Data
The immersed boundary (IB) method is a mathematical framework for fluid–structure interaction problems (FSI) that was originally developed to simulate flows around heart valves. Direct comparison of FSI simula...
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Article
MRV challenge 2: phase locked turbulent measurements in a roughness array
Magnetic resonance velocimetry (MRV) provides capabilities to measure three velocity components across three-dimensional fields of view without the need for optical accessibility. Predominant usage of the tech...
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Article
Isotropic turbulence apparatus with a large vertical extent
An experimental flow facility for sustaining a column of nearly isotropic turbulence in air has been developed. Four arrays of synthetic jet actuators are arranged along the walls of a vertical tower, producin...
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Article
Author Correction: Cytochrome P450 oxidoreductase contributes to phospholipid peroxidation in ferroptosis
A Correction to this paper has been published: https://doi.org/10.1038/s41589-021-00767-w.
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Article
In Vitro Assessment of Right Ventricular Outflow Tract Anatomy and Valve Orientation Effects on Bioprosthetic Pulmonary Valve Hemodynamics
The congenital heart defect Tetralogy of Fallot (ToF) affects 1 in 2500 newborns annually in the US and typically requires surgical repair of the right ventricular outflow tract (RVOT) early in life, with vari...
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Article
Plasticity of ether lipids promotes ferroptosis susceptibility and evasion
Ferroptosis—an iron-dependent, non-apoptotic cell death process—is involved in various degenerative diseases and represents a targetable susceptibility in certain cancers1. The ferroptosis-susceptible cell state ...
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Article
The 2019 MRV challenge: turbulent flow through a U-bend
While magnetic resonance velocimetry (MRV) has been used in technological flow studies for over 30 years, it has not yet reached the levels of usage as more traditional experimental techniques such as particle...
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Article
Selective covalent targeting of GPX4 using masked nitrile-oxide electrophiles
We recently described glutathione peroxidase 4 (GPX4) as a promising target for killing therapy-resistant cancer cells via ferroptosis. The onset of therapy resistance by multiple types of treatment results in...
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Article
Cytochrome P450 oxidoreductase contributes to phospholipid peroxidation in ferroptosis
Ferroptosis is widely involved in degenerative diseases in various tissues including kidney, liver and brain, and is a targetable vulnerability in multiple primary and therapy-resistant cancers. Accumulation o...
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Article
An improved three-dimensional concentration measurement technique using magnetic resonance imaging
Magnetic resonance concentration (MRC) was introduced by Benson et al. (Exp Fluids 49:43–55, 2010) to obtain three-dimensional, time-averaged concentration fields in complex turbulent flows without the need fo...
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Article
Transport and dispersion of particle-Laden streaks in a standardized human nasal geometry
Microparticle transport in the human airway is an important problem with major implications for global healthcare. However, nasal cavity flows are not well understood due to morphological variations and the di...
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Article
3D MRI measurements of the effects of wind direction on flow characteristics and contaminant dispersion in a model urban canopy
Three dimensional velocity fields and contaminant dispersion within an evenly spaced orthogonal array of cubic buildings (height = H) with a central tall building (height = 3H) were studied to examine the infl...
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Article
Open AccessA GPX4-dependent cancer cell state underlies the clear-cell morphology and confers sensitivity to ferroptosis
Clear-cell carcinomas (CCCs) are a histological group of highly aggressive malignancies commonly originating in the kidney and ovary. CCCs are distinguished by aberrant lipid and glycogen accumulation and are ...
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Article
Unsteady vortex structures in the wake of nonaxisymmetric bumps using spiral MRV
The temporal characteristics of the wake structure behind a nonaxisymmetric bump are studied using spiral magnetic resonance velocimetry (MRV) to measure time-series of all three velocity components in y–z-planes...
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Article
Investigation of geometric sensitivity of a non-axisymmetric bump: 3D mean velocity measurements
The geometric sensitivity of a non-axisymmetric bump with \(H/\delta =2\) ...
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Article
3D Measurements of coupled freestream turbulence and secondary flow effects on film cooling
The effect of freestream turbulence on a single round film cooling hole is examined at two turbulence levels of 5 and 8% and compared to a baseline low freestream turbulence case. The hole is inclined at 30 ...
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Article
Measurements in discrete hole film cooling behavior with periodic freestream unsteadiness
Magnetic resonance imaging (MRI) techniques were used to investigate a discrete, \(30^{\circ }\) ...
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Article
Drug-tolerant persister cancer cells are vulnerable to GPX4 inhibition
Cancer persister cells, which survive cytotoxic treatments, are shown to be sensitive to inhibition of the lipid hydroperoxidase GPX4.
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Article
Dependency of a therapy-resistant state of cancer cells on a lipid peroxidase pathway
Therapy-resistant cancer cell states identified across diverse contexts are selectively vulnerable to ferroptotic cell death induced by inhibition of lipid peroxidase pathways converging on GPX4.
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Article
Turbulent Scalar Mixing in a Skewed Jet in Crossflow: Experiments and Modeling
Turbulent mixing of an inclined, skewed jet injected into a crossflow is investigated using MRI-based experiments and a high-fidelity LES of the same configuration. The MRI technique provides three-dimensional...
