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Article
Open AccessApolipoprotein A-IV binds αIIbβ3 integrin and inhibits thrombosis
Platelet αIIbβ3 integrin and its ligands are essential for thrombosis and hemostasis, and play key roles in myocardial infarction and stroke. Here we show that apolipoprotein A-IV (apoA-IV) can be isolated fro...
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Article
Open AccessActivated NK cells cause placental dysfunction and miscarriages in fetal alloimmune thrombocytopenia
Miscarriage and intrauterine growth restriction (IUGR) are devastating complications in fetal/neonatal alloimmune thrombocytopenia (FNAIT). We previously reported the mechanisms for bleeding diatheses, but it ...
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Article
Open AccessDesialylation is a mechanism of Fc-independent platelet clearance and a therapeutic target in immune thrombocytopenia
Immune thrombocytopenia (ITP) is a common bleeding disorder caused primarily by autoantibodies against platelet GPIIbIIIa and/or the GPIb complex. Current theory suggests that antibody-mediated platelet destru...
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Article
Markers of platelet apoptosis: methodology and applications
Apoptosis, or programmed cell death, is a physiological mechanism that serves for controlled deletion of damaged cells. While long attributed exclusively to nucleated cells, over recent years it has been recog...
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Article
Platelets and the immune continuum
Platelets have a plethora of soluble and cell-associated immunomodulatory molecules that can enhance and in some instances inhibit immune responses in a variet...
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Article
Platelets and innate immunity
Although platelets are best known as primary mediators of hemostasis, this function intimately associates them with inflammatory processes, and it has been increasingly recognized that platelets play an active...
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Article
Intravenous immunoglobulin ameliorates ITP via activating Fcγ receptors on dendritic cells
Despite a more than 20-year experience of therapeutic benefit, the relevant molecular and cellular targets of intravenous immunoglobulin (IVIg) in autoimmune disease remain unclear. Contrary to the prevailing ...
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Article
The Relationship of von Willebrand Factor Binding to Activated Platelets from Healthy Neonates and Adults
von Willebrand Factor (VWF) is important in platelet adhesion and shear-dependent platelet activation. We performed flow cytometric analyses of VWF binding to and activation of platelets from healthy neonates,...
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Article
Platelet-Surface Glycoproteins in Healthy and Preeclamptic Mothers and Their Newborn Infants
Preeclampsia, a common complication of pregnancy, contributes significantly to maternal and fetal morbidity and mortality. It may lead to both quantitative and qualitative defects of maternal and neonatal plat...
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Article
Changing patterns of transfusion practice in a tertiary care hospital from 1977 to 1984
Patterns of blood transfusion practice over an eight-year-period (1977–1984) are described. Use of blood and blood products increased annually as did the number of patients crossmatched and transfused. Program...
