10 Result(s)
within
John F. McDonald
Human Genetics
-
Article
Regulatory gene adaptation: An evolutionary model
There is increasing support for the notion that changes in regulatory loci have played a major role in eukaryotic evolution. Assuming a model of genetic regulation based upon presently accepted views of the or...
-
Article
Long terminal repeat retrotransposons of Oryza sativa
Long terminal repeat (LTR) retrotransposons constitute a major fraction of the genomes of higher plants. For example, retrotransposons comprise more than 50% of the maize genome and more than 90% of the wheat ...
-
Article
Long terminal repeat retrotransposons of Mus musculus
Long terminal repeat (LTR) retrotransposons make up a large fraction of the typical mammalian genome. They comprise about 8% of the human genome and approximately 10% of the mouse genome. On account of their a...
-
Article
Ancient retroviral insertions among human populations
Human endogenous retroviruses (HERVs) represent vestiges of ancient infections that resulted in stable integration of the viral genome. These insertional elements of viral origin are in fact molecular fossils ...
-
Article
Open AccessIdentification, characterization and comparative genomics of chimpanzee endogenous retroviruses
Retrotransposons, the most abundant and widespread class of eukaryotic transposable elements, are believed to play a significant role in mutation and disease and to have contributed significantly to the evolut...
-
Article
Open AccessGene expression profiling supports the hypothesis that human ovarian surface epithelia are multipotent and capable of serving as ovarian cancer initiating cells
Accumulating evidence suggests that somatic stem cells undergo mutagenic transformation into cancer initiating cells. The serous subtype of ovarian adenocarcinoma in humans has been hypothesized to arise from ...
-
Article
Open AccessCharacterization and potential functional significance of human-chimpanzee large INDEL variation
Although humans and chimpanzees have accumulated significant differences in a number of phenotypic traits since diverging from a common ancestor about six million years ago, their genomes are more than 98.5% i...
-
Article
Open AccessThe effects of MicroRNA transfections on global patterns of gene expression in ovarian cancer cells are functionally coordinated
MicroRNAs (miRNAs) are a class of small RNAs that have been linked to a number of diseases including cancer. The potential application of miRNAs in the diagnostics and therapeutics of ovarian and other cancers...
-
Article
Open AccessIntegrated sequence and expression analysis of ovarian cancer structural variants underscores the importance of gene fusion regulation
Genomic rearrangements or structural variants (SVs) are one of the most common classes of mutations in cancer.
-
Article
Open AccessDe novo assembly and characterization of breast cancer transcriptomes identifies large numbers of novel fusion-gene transcripts of potential functional significance
Gene-fusion or chimeric transcripts have been implicated in the onset and progression of a variety of cancers. Massively parallel RNA sequencing (RNA-Seq) of the cellular transcriptome is a promising approach ...
