4 Result(s)
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Article
Open AccessGene expression profiling supports the hypothesis that human ovarian surface epithelia are multipotent and capable of serving as ovarian cancer initiating cells
Accumulating evidence suggests that somatic stem cells undergo mutagenic transformation into cancer initiating cells. The serous subtype of ovarian adenocarcinoma in humans has been hypothesized to arise from ...
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Article
Open AccessThe effects of MicroRNA transfections on global patterns of gene expression in ovarian cancer cells are functionally coordinated
MicroRNAs (miRNAs) are a class of small RNAs that have been linked to a number of diseases including cancer. The potential application of miRNAs in the diagnostics and therapeutics of ovarian and other cancers...
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Article
Open AccessIntegrated sequence and expression analysis of ovarian cancer structural variants underscores the importance of gene fusion regulation
Genomic rearrangements or structural variants (SVs) are one of the most common classes of mutations in cancer.
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Article
Open AccessDe novo assembly and characterization of breast cancer transcriptomes identifies large numbers of novel fusion-gene transcripts of potential functional significance
Gene-fusion or chimeric transcripts have been implicated in the onset and progression of a variety of cancers. Massively parallel RNA sequencing (RNA-Seq) of the cellular transcriptome is a promising approach ...
