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Article
RNA’s Role in the Origins of Life: An Agentic ‘Manager’, or Recipient of ‘Off-loaded’ Constraints?
In his Target Article, Deacon develops simple models that assist in understanding the role of RNA in the origins of life. However, his models fail to adequately represent an important evolutionary dynamic. Cen...
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Article
Open AccessThe Origins of Life: The Managed-Metabolism Hypothesis
The ‘managed-metabolism’ hypothesis suggests that a ‘cooperation barrier’ must be overcome if self-producing chemical organizations are to undergo the transition from non-life to life. This dynamical barrier p...
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Article
Open AccessComparison of small-area deprivation measures as predictors of chronic disease burden in a low-income population
Measures of small-area deprivation may be valuable in geographically targeting limited resources to prevent, diagnose, and effectively manage chronic conditions in vulnerable populations. We developed a census...
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Article
The Future of Life and What it Means for Humanity
Vidal’s (Found Sci, 2010) and Rottiers’s (Found Sci, 2010) commentaries on my (2010) paper raised a number of important issues about the possible future trajectory of evolution and its implications for humanity. ...
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Article
Open AccessDiabetes and the socioeconomic and built environment: geovisualization of disease prevalence and potential contextual associations using ring maps
Efforts to stem the diabetes epidemic in the United States and other countries must take into account a complex array of individual, social, economic, and built environmental factors. Increasingly, scientists ...
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Article
The Meaning of Life in a Develo** Universe
The evolution of life on Earth has produced an organism that is beginning to model and understand its own evolution and the possible future evolution of life in the universe. These models and associated eviden...
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Article
HVI and HVII mitochondrial DNA data in Apaches and Navajos
Most mtDNA studies on Native Americans have concentrated on hypervariable region I (HVI) sequence data. Mitochondrial DNA haplotype data from hypervariable regions I and II (HVI and HVII) have been compiled fr...
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Chapter and Conference Paper
Rebuilding the visible man
This paper describes a collection of techniques designed to create photo-realistic computer models of the National Library of Medicine's Visible Man. An image segmentation algorithm is described which segments...
