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Article
The small molecule CLP257 does not modify activity of the K+–Cl− co-transporter KCC2 but does potentiate GABAA receptor activity
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Article
Open AccessProtein misfolding in neurodegenerative diseases: implications and strategies
A hallmark of neurodegenerative proteinopathies is the formation of misfolded protein aggregates that cause cellular toxicity and contribute to cellular proteostatic collapse. Therapeutic options are currently...
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Article
Open AccessBalanced translocation linked to psychiatric disorder, glutamate, and cortical structure/function
Rare genetic variants of large effect can help elucidate the pathophysiology of brain disorders. Here we expand the clinical and genetic analyses of a family with a (1;11)(q42;q14.3) translocation multiply aff...
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Chapter
5-HT2C Agonists as Therapeutics for the Treatment of Schizophrenia
The 5-HT2C receptor is a highly complex, highly regulated receptor which is widely distributed throughout the brain. The 5-HT2C receptor couples to multiple signal transduction pathways leading to engagement of a...
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Article
Preclinical assessment of an adjunctive treatment approach for cognitive impairment associated with schizophrenia using the alpha7 nicotinic acetylcholine receptor agonist WYE-103914/SEN34625
α7 nicotinic acetylcholine receptor (nAChR) agonists are proposed as candidate agents for the adjunctive treatment of cognitive deficits associated with schizophrenia. Despite the pursuit of such an approach c...
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Article
Acid sensing ion channel (ASIC) inhibitors exhibit anxiolytic-like activity in preclinical pharmacological models
Acid sensing ion channels (ASICs) are proton-gated ion channels located in the central and peripheral nervous systems. Of particular interest is ASIC1a, which is located in areas associated with fear and anxie...
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Article
Turning up the pace of ion channel screening in drug discovery
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Article
QoS-Aware Network-supported Architecture to Distribute Application Flows over Multiple Network Interfaces for B3G Users
Users in the Beyond-Third-Generation (B3G) wireless system expect to receive ubiquitous communication services with customised quality-of-service (QoS) commitments for different applications, preferably in a w...
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Article
High-throughput electrophysiology: an emerging paradigm for ion-channel screening and physiology
Ion channels represent an important class of druggable targets; however, it is generally appreciated in the field that ion-channel targeted drug discovery has ...
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Article
The Concept of a Personal Distributed Environment for Wireless Service Delivery
Traditionally wireless service delivery has been restricted in scope to voice and text messaging and has been targeted at a single user device. Increasing interest is now being shown in ubiquitous delivery of ...
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Article
Antidepressant-like effects of the novel, selective, 5-HT2C receptor agonist WAY-163909 in rodents
Activation of one or more of the serotonin (5-HT) receptors may play a role in mediating the antidepressant effects of SSRIs.
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Chapter
Language, Faith and Communication
What have been called the Peace Process and, before that, the scandalous murderous terrorist activity of paramilitary groups have made their tortuous way through myriads of press conferences, speeches, sermons...
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Article
Guest Editorial
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Article
Editorial
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Article
On the Dynamics of Link Adaptation Updating Periods for Packet Switched Systems
Link Adaptation is an adaptive radio link technique that selects atransport mode, from a set of predefined modes of varyingrobustness, depending on the channel quality. One of theparameters that has to be defi...
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Chapter
Coding
Coding plays a major role in the efficient transmission and improved error performance of the third generation mobile systems, as well as any future wireless system. This chapter will cover some major techniqu...
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Chapter
Functional Evaluation of the Benzodiazepine Cholecystokinin Type-B Receptor Antagonists L-365,260, L-740,093, and YM022
Two identified receptor subtypes, designated type-A and type-B (1), mediate the physiological actions of the brain/gut peptide cholecystokinin (CCK). In the central nervous system the CCK-B receptor represents...
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Chapter and Conference Paper
Assessment of 3rd generation mobile systems by simulation
This paper describes the structure of a simulator developed for the ATDMA project for assessing the performance of an adaptive radio interface in a 3rd generation cellular system. Particular attention is given...
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Article
Inhibition by excitatory sulphur amino acids of the high-affinityl-glutamate transporter in synaptosomes and in primary cultures of cortical astrocytes and cerebellar neurons
A detailed kinetic study of the inhibitory effects ofl- andd-enantiomers of cysteate, cysteine sulphinate, homocysteine sulphinate, homocysteate, and S-sulpho-cysteine on the neuronal, astroglial and synaptosomal...
