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  1. Article

    Open Access

    Introducing neurofilament light chain measure in psychiatry: current evidence, opportunities, and pitfalls

    The recent introduction of new-generation immunoassay methods allows the reliable quantification of structural brain markers in peripheral matrices. Neurofilament light chain (NfL), a neuron-specific cytoskele...

    Francesco Bavato, Christian Barro, Laura K. Schnider, Joel Simrén in Molecular Psychiatry (2024)

  2. Article

    Open Access

    Central nervous system biomarkers GFAp and NfL associate with post-acute cognitive impairment and fatigue following critical COVID-19

    A high proportion of patients with coronavirus disease 2019 (COVID-19) experience post-acute COVID-19, including neuropsychiatric symptoms. Objective signs of central nervous system (CNS) damage can be investi...

    Lovisa Bark, Ing-Marie Larsson, Ewa Wallin, Joel Simrén in Scientific Reports (2023)

  3. Article

    Open Access

    CSF tau368/total-tau ratio reflects cognitive performance and neocortical tau better compared to p-tau181 and p-tau217 in cognitively impaired individuals

    Cerebrospinal fluid (CSF) tau biomarkers are reliable diagnostic markers for Alzheimer’s disease (AD). However, their strong association with amyloid pathology may limit their reliability as specific markers o...

    Joel Simrén, Wagner S. Brum, Nicholas J. Ashton in Alzheimer's Research & Therapy (2022)

  4. No Access

    Article

    Reply to Dr. Arieli regarding our article protein tau concentration in blood increases after SCUBA diving: an observational study published in European journal of applied physiology 2022;122:993-1005

    Anders Rosén, Mikael Gennser, Nicklas Oscarsson in European Journal of Applied Physiology (2022)

  5. Article

    Open Access

    Diagnostic value of serum versus plasma phospho-tau for Alzheimer’s disease

    Blood phosphorylated tau (p-tau) forms are promising Alzheimer’s disease (AD) biomarkers, but validation in matrices other than ethylenediaminetetraacetic acid (EDTA) plasma is limited. Firstly, we assessed th...

    Przemysław R. Kac, Fernando Gonzalez-Ortiz, Joel Simrén in Alzheimer's Research & Therapy (2022)

  6. Article

    Open Access

    Plasma biomarkers for Alzheimer’s Disease in relation to neuropathology and cognitive change

    Plasma biomarkers related to amyloid, tau, and neurodegeneration (ATN) show great promise for identifying these pathological features of Alzheimer’s Disease (AD) as shown by recent clinical studies and selecte...

    Denis S. Smirnov, Nicholas J. Ashton, Kaj Blennow in Acta Neuropathologica (2022)

  7. Article

    Open Access

    Protein tau concentration in blood increases after SCUBA diving: an observational study

    It is speculated that diving might be harmful to the nervous system. The aim of this study was to determine if established markers of neuronal injury were increased in the blood after diving.

    Anders Rosén, Mikael Gennser, Nicklas Oscarsson in European Journal of Applied Physiology (2022)