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Rule of Law as a Framework within the ASEAN Community

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    Open Access

    HOX epimutations driven by maternal SMCHD1/LRIF1 haploinsufficiency trigger homeotic transformations in genetically wildtype offspring

    The body plan of animals is laid out by an evolutionary-conserved HOX code which is colinearly transcribed after zygotic genome activation (ZGA). Here we report that SMCHD1, a chromatin-modifying enzyme needed...

    Shifeng Xue, Thanh Thao Nguyen Ly, Raunak S. Vijayakar… in Nature Communications (2022)

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