Page
%P
-
Article
Open AccessFOXO1 enhances CAR T cell stemness, metabolic fitness and efficacy
Chimeric antigen receptor (CAR) T cell therapy has transformed the treatment of haematological malignancies such as acute lymphoblastic leukaemia, B cell lymphoma and multiple myeloma1–4, but the efficacy of CAR ...
-
Article
Open AccessA2AR eGFP reporter mouse enables elucidation of A2AR expression dynamics during anti-tumor immune responses
There is significant clinical interest in targeting adenosine-mediated immunosuppression, with several small molecule inhibitors having been developed for targeting the A2AR receptor. Understanding of the mechani...
