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Article
Rescue designs in analgesic trials from 0 to 2 years of age: sco** review
Pediatric analgesic trials are challenging, especially in newborns and infants. Following an FDA-academic consensus meeting, we analyzed pragmatic rescue designs in postoperative trials of local anesthetics, a...
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Article
Open AccessGenome-wide association analysis of insomnia using data from Partners Biobank
Insomnia is one of the most prevalent and burdensome mental disorders worldwide, affecting between 10–20% of adults and up to 48% of the geriatric population. It is further associated with substance usage and ...
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Article
Open AccessIntroducing COSMOS: a Web Platform for Multimodal Game-Based Psychological Assessment Geared Towards Open Science Practice
We have established the COgnitive Science Metrics Online Survey (COSMOS) platform that contains a digital psychometrics toolset in the guise of applied games measuring a wide range of cognitive functions. Here, w...
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Article
Open AccessEffects and Components of Placebos with a Psychological Treatment Rationale – Three Randomized-Controlled Studies
In recent years, placebos have evolved from a mean to control for ‘therapeutic chaff’ to something that has clinically relevant effects with biological underpinning and that is considered to have clinical as w...
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Article
Vigilance and Avoidance of Threat in the Eye Movements of Children with Separation Anxiety Disorder
The vigilance-avoidance attention pattern is found in anxious adults, who initially gaze more at threatening pictures than nonanxious adults (vigilance), but subsequently gaze less at them than nonanxious adults ...
