9 Result(s)
within
Joaquín Dopazo
Biomedicine
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Article
Open AccessReal-world evidence with a retrospective cohort of 15,968 COVID-19 hospitalized patients suggests 21 new effective treatments
Despite the extensive vaccination campaigns in many countries, COVID-19 is still a major worldwide health problem because of its associated morbidity and mortality. Therefore, finding efficient treatments as f...
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Article
Open AccessGenome-wide analysis of DNA methylation in Hirschsprung enteric precursor cells: unraveling the epigenetic landscape of enteric nervous system development
Hirschsprung disease (HSCR, OMIM 142623) is a rare congenital disorder that results from a failure to fully colonize the gut by enteric precursor cells (EPCs) derived from the neural crest. Such incomplete gut...
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Article
Open AccessBRCA1 Alternative splicing landscape in breast tissue samples
BRCA1 is a key protein in cell network, involved in DNA repair pathways and cell cycle. Recently, the ENIGMA consortium has reported a high number of alternative splicing (AS) events at this locus in blood-derive...
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Article
Open AccessA map of human microRNA variation uncovers unexpectedly high levels of variability
MicroRNAs (miRNAs) are key components of the gene regulatory network in many species. During the past few years, these regulatory elements have been shown to be involved in an increasing number and range of di...
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Article
Open AccessA large scale survey reveals that chromosomal copy-number alterations significantly affect gene modules involved in cancer initiation and progression
Recent observations point towards the existence of a large number of neighborhoods composed of functionally-related gene modules that lie together in the genome. This local component in the distribution of the...
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Article
Open AccessDNA methylation epigenotypes in breast cancer molecular subtypes
Identification of gene expression-based breast cancer subtypes is considered a critical means of prognostication. Genetic mutations along with epigenetic alterations contribute to gene-expression changes occur...
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Article
Open AccessBiological processes, properties and molecular wiring diagrams of candidate low-penetrance breast cancer susceptibility genes
Recent advances in whole-genome association studies (WGASs) for human cancer risk are beginning to provide the part lists of low-penetrance susceptibility genes. However, statistical analysis in these studies ...
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Chapter
Evolution and Tropism of Transmissible Gastroenteritis Coronavirus
Transmissible gastroenteritis coronavirus (TGEV) is an enteropathogenic coronavirus isolated for the first time in 1946. Nonenteropathogenic porcine respiratory coronaviruses (PRCVs) have been derived from TGE...
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Chapter
Genetic Variability and Antigenic Diversity of Foot-and-Mouth Disease Virus
Foot-and-mouth disease (FMD) is an acute systemic disease of cloven-hooved animals, including cattle, swine, sheep, and goats. Despite mortality rates being generally below 5%, FMD severely decreases livestock...
