5 Result(s)
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Joanna Maria Merchut-Maya
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Article
Open AccessNAD+ regulates nucleotide metabolism and genomic DNA replication
The intricate orchestration of enzymatic activities involving nicotinamide adenine dinucleotide (NAD+) is essential for maintaining metabolic homeostasis and preserving genomic integrity. As a co-enzyme, NAD+ pla...
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Article
Human cytomegalovirus hijacks host stress response fueling replication stress and genome instability
Viral infections enhance cancer risk and threaten host genome integrity. Although human cytomegalovirus (HCMV) proteins have been detected in a wide spectrum of human malignancies and HCMV infections have been...
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Article
AMBRA1 regulates cyclin D to guard S-phase entry and genomic integrity
Mammalian development, adult tissue homeostasis and the avoidance of severe diseases including cancer require a properly orchestrated cell cycle, as well as error-free genome maintenance. The key cell-fate dec...
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Article
Open AccessAutophagy role(s) in response to oncogenes and DNA replication stress
Autophagy is an evolutionarily conserved process that captures aberrant intracellular proteins and/or damaged organelles for delivery to lysosomes, with implications for cellular and organismal homeostasis, ag...
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Article
High speed of fork progression induces DNA replication stress and genomic instability
Accurate replication of DNA requires stringent regulation to ensure genome integrity. In human cells, thousands of origins of replication are coordinately activated during S phase, and the velocity of replicat...
