12 Result(s)
within
Joana Caetano-Lopes
-
Article
Open AccessImproving the DNA specificity and applicability of base editing through protein engineering and protein delivery
We recently developed base editing, a genome-editing approach that enables the programmable conversion of one base pair into another without double-stranded DNA cleavage, excess stochastic insertions and delet...
-
Reference Work Entry In depth
Bone Markers Throughout Sexual Development: Epidemiological Significance and Population-Based Findings
Bone markers are used in adults to predict fracture risk and to monitor anabolic or catabolic therapies. Much less is known about their usefulness during childhood and adolescence when, besides remodeling, bon...
-
Living Reference Work Entry In depth
Bone Markers Throughout Sexual Development: Epidemiological Significance and Population-Based Findings
Bone markers are used in adults to predict fracture risk and to monitor anabolic or catabolic therapies. Much less is known about their usefulness during childhood and adolescence when, besides remodeling, bon...
-
Article
Rheumatoid Arthritis Bone Fragility Is Associated With Upregulation of IL17 and DKK1 Gene Expression
Our aim was to compare bone gene expression in rheumatoid arthritis (RA) and primary osteoporosis (OP) patients. Secondary aims were to determine the association of gene expression of the Wnt/β-catenin signali...
-
Article
Open AccessAt the moment of occurrence of a fragility hip fracture, men have higher mechanical properties values in comparison with women
It is well established that males have lower fracture risk in comparison with females, which suggests a higher bone resistance in men. The aim of our study was to find out if in older patients with hip fragili...
-
Article
Smoking is a predictor of worse trabecular mechanical performance in hip fragility fracture patients
Clinical risk factors (CRFs) are established predictors of fracture events. However, the influence of individual CRFs on trabecular mechanical fragility is still a subject of debate. In this study, we aimed to...
-
Article
TNF promoter -308 G>A and LTA 252 A>G polymorphisms in Portuguese patients with systemic lupus erythematosus
The polymorphism of the tumor necrosis factor (TNF) promoter gene at position -308 and that of the lymphotoxin alpha (LTA) gene at position 252 have been implicated as genetic risk factors for systemic lupus e...
-
Article
Open AccessRheumatoid arthritis is associated with increased DKK1 expression and disturbances in the bone turnover regulating genes
-
Article
Open AccessApolipoprotein E and undercaboxylated osteocalcin are associated with bone fragility but not with bone mineral density in osteoarthritis patients
-
Article
Open AccessChronic arthritis leads to disturbances in the bone collagen network
In this study we used a mice model of chronic arthritis to evaluate if bone fragility induced by chronic inflammation is associated with an imbalance in bone turnover and also a disorganization of the bone typ...
-
Article
Assessment of laboratory measurements and −308 TNFα gene promoter polymorphisms in normal bone mineral density
The aim of this study was to identify and evaluate laboratory parameters associated with normal bone mineral density (BMD) and to test if −308 tumour necrosis factor (TNF) alpha gene promoter polymorphisms cou...
-
Article
Open AccessContribution for new genetic markers of rheumatoid arthritis activity and severity: sequencing of the tumor necrosis factor-alpha gene promoter
The objective of this study was to assess whether clinical measures of rheumatoid arthritis activity and severity were influenced by tumor necrosis factor-alpha (TNF-α) promoter genotype/haplotype markers. Each p...
