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Article
Anticorrosive properties in 1020 steel of an alkaloid-rich extract obtained from the jaborandi biomass (Pilocarpus microphyllus staff ex wardlew) of the pilocarpine industrial production chain
The annual costs related to corrosion and its prevention have been responsible for a significant part of the Gross Domestic Product in the Western world. In addition to economic costs and technological delays,...
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Article
A randomised, crossover trial exploring the patient perspective and effectiveness of biosimilar adalimumab transition: IBD reference and biosimilar adalimumab cross over study (iBaSS)
Patient satisfaction has been positively associated with adherence which is expected to impact outcomes. Although vital for successful implementation of biosimilar medicines, little is known about the patient ...
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Article
Open AccessThe Role of 5-Hydroxymethylcytosine as a Potential Epigenetic Biomarker in a Large Series of Thyroid Neoplasms
Cytosine modifications at the 5-carbon position play a critical role in gene expression regulation and have been implicated in cancer development. 5-Hydroxymethylcytosine (5hmC), arising from 5-methylcytosine ...
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Chapter and Conference Paper
Cybersecurity in Industry 4.0 and Internet of Things: Challenges and Opportunities
This article provides an in-depth analysis of the challenges and opportunities associated with cybersecurity in Industry 4.0 and the Internet of Things (IoT). The article highlights the importance of securing ...
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Article
Open AccessExploring mixed lepton-quark interactions in non-resonant leptoquark production at the LHC
Searches for new physics (NP) at particle colliders typically involve multivariate analysis of kinematic distributions of final state particles produced in a decay of a hypothetical NP resonance. Since the pai...
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Article
Open AccessDeep learning searches for vector-like leptons at the LHC and electron/muon colliders
The discovery potential of both singlet and doublet vector-like leptons (VLLs) at the Large Hadron Collider (LHC) as well as at the not-so-far future muon and electron machines is explored. The focus is on a s...
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Article
Open AccessThe role of habitat features in patterns of population connectivity of two Mediterranean amphibians in arid landscapes of central Iberia
Mediterranean wetland ecosystems are in continuous decline due to human pressure. Amphibians are key elements of biotic communities of Mediterranean temporary ponds and streams, and their persistence depends o...
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Article
Open AccessDiverse monogenic subforms of human spermatogenic failure
Non-obstructive azoospermia (NOA) is the most severe form of male infertility and typically incurable. Defining the genetic basis of NOA has proven challenging, and the most advanced classification of NOA subf...
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Article
Open AccessImmune and spermatogenesis-related loci are involved in the development of extreme patterns of male infertility
We conducted a genome-wide association study in a large population of infertile men due to unexplained spermatogenic failure (SPGF). More than seven million genetic variants were analysed in 1,274 SPGF cases a...
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Article
Open AccessPhenomenology at the large hadron collider with deep learning: the case of vector-like quarks decaying to light jets
In this work, we continue our exploration of TeV-scale vector-like fermion signatures inspired by a Grand Unification scenario based on the trinification gauge group. A particular focus is given to pair-produc...
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Article
Open AccessCollider signatures of vector-like fermions from a flavor symmetric model
We propose a model with two Higgs doublets and several SU(2) scalar singlets with a global non-Abelian flavor symmetry ...
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Article
Open AccessAn autonomous mobile manipulator to build outdoor structures consisting of heterogeneous brick patterns
This paper describes the implementation of an autonomous mobile manipulator to build outdoor structures consisting of heterogeneous brick patterns, finding applications in different industrial automation, manu...
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Article
Open AccessPhenomenology of vector-like leptons with Deep Learning at the Large Hadron Collider
In this paper, a model inspired by Grand Unification principles featuring three generations of vector-like fermions, new Higgs doublets and a rich neutrino sector at the low scale is presented. Using the state...
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Article
Correction to: Disruption of human meiotic telomere complex genes TERB1, TERB2 and MAJIN in men with non-obstructive azoospermia
In the original article published, the family name of the 6th author is published incorrectly.
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Chapter and Conference Paper
IoT Sensing Box to Support Small-Scale Farming in Africa
Small-scale farming has an important role in agriculture. Driven by the popularization of the Internet of things (IoT), this paper presents an IoT sensing box prototype coupled with soil analysis through compu...
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Article
Open AccessLate Quaternary range shifts of marcescent oaks unveil the dynamics of a major biogeographic transition in southern Europe
Marcescent forests are ecotones distributed across southern Europe that host increased levels of biodiversity but their persistence is threatened by global change. Here we study the range dynamics of these for...
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Article
Correction to: Biologic Drug Quality Assurance to Optimize HER2+ Breast Cancer Treatment: Insights from Development of the Trastuzumab Biosimilar SB3
The article Biologic Drug Quality Assurance to Optimize HER2+ Breast Cancer Treatment: Insights from Development of the Trastuzumab Biosimilar SB3,
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Article
Open AccessBiologic Drug Quality Assurance to Optimize HER2 + Breast Cancer Treatment: Insights from Development of the Trastuzumab Biosimilar SB3
SB3 is a biosimilar of trastuzumab that has been approved for use in the treatment of human epidermal growth factor 2-positive breast cancer and human epidermal growth factor 2-positive gastric cancer. Antibod...
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Chapter
Insights on the Formulation of Recombinant Proteins
Recombinant proteins are large and complex molecules, whose therapeutic activity highly depends on their structure. Formulation of biopharmaceuticals aims at stabilizing protein conformation, promoting its eff...
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Article
SocRob@Home
This paper describes the SocRob@Home robot system, consisting of a mobile robot (MBOT) equipped with several sensors and actuators, including a manipulator arm, and several software modules that provide the sk...
