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Article
Improving survival in recurrent medulloblastoma: earlier detection, better treatment or still an impasse?
Early detection of relapse has been advocated to improve survival in children with recurrent medulloblastoma. However, the prognostic factors and the longer term outcome of these patients remains unclear. Patt...
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Article
Sensitive detection of occult Ewing's cells by the reverse transcriptase-polymerase chain reaction
Recently, Ewing's tumours have been shown to carry specific hybrid transcripts resulting from the fusion of the EWS gene with FLI-1 or ERG genes. Based on the sensitivity and specificity of the detection of th...
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Article
Double megatherapy and autologous bone marrow transplantation for advanced neuroblastoma: the LMCE2 study
In the LMCE1 study using a single course of megatherapy most of the relapses occurred during the first 2 years after autologous bone marrow transplantation. A second pilot study (LMCE2) was therefore set up us...
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Article
Short duration, high dose, alternating chemotherapy in metastatic neuroblastoma. (ENSG 3C induction regimen)
Fifty-one children, aged from 15 months to 13 years 5 months with metastatic neuroblastoma presenting sequentially at the participating institutions received four 3 to 4 weekly courses of high dose multiagent ...
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Article
Immunological detection of neuroblastoma cells in bone marrow harvested for autologous transplantation
In about 50% of patients with stage IV neuroblastoma, micrometastases are present in the bone marrow when it is harvested for an autograft to follow induction therapy, and the risk of graft contamination by ne...
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Article
GROWTH AND ENDOCRINE FUNCTION AFTER BONE MARROW TRANSPLANTATION (BMT) WITH OR WITHOUT TOTAL BODY IRRADIATION (TBI)
TBI preparing to BMT is frequently followed by growth retardation. As GH deficiency (GHD) is a well known complication of cranial irradiation, the purpose of this study was to evaluate the risk of GHD after TB...
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Article
SEQUENTIAL OCCURRENCE OF ENDOCRINE DISTURBANCES IN CHILDREN TREATED FOR OPTIC GLIOMAS (OG)
Children with OG are at major risk for short final stature because of the combined effects of GH deficiency (GHD) and central precocious puberty (PP). In order to better establish our therapeutic strategy, the...