-
Article
Modular chimeric cytokine receptors with leucine zippers enhance the antitumour activity of CAR T cells via JAK/STAT signalling
The limited availability of cytokines in solid tumours hinders maintenance of the antitumour activity of chimeric antigen receptor (CAR) T cells. Cytokine receptor signalling pathways in CAR T cells can be act...
-
Article
CXCR6 orchestrates brain CD8+ T cell residency and limits mouse Alzheimer’s disease pathology
Neurodegenerative diseases, including Alzheimer’s disease (AD), are characterized by innate immune-mediated inflammation, but functional and mechanistic effects of the adaptive immune system remain unclear. He...
-
Article
Reply to: Ricolinostat is not a highly selective HDAC6 inhibitor
-
Article
Targeting DNA polymerase β elicits synthetic lethality with mismatch repair deficiency in acute lymphoblastic leukemia
Mismatch repair (MMR) deficiency has been linked to thiopurine resistance and hypermutation in relapsed acute lymphoblastic leukemia (ALL). However, the repair mechanism of thiopurine-induced DNA damage in the...
-
Article
Open AccessNetBID2 provides comprehensive hidden driver analysis
Many signaling and other genes known as “hidden” drivers may not be genetically or epigenetically altered or differentially expressed at the mRNA or protein levels, but, rather, drive a phenotype such as tumor...
-
Article
Open AccessSpatiotemporal regulation of cholangiocarcinoma growth and dissemination by peritumoral myofibroblasts in a Vcam1-dependent manner
Intrahepatic cholangiocarcinoma (iCCA) is characterized by its highly desmoplastic stroma. Myofibroblasts (MFs) are present both within the tumor mass (intratumoral MFs, iMFs) and at the tumor border (peritumo...
-
Article
Open AccessRibonucleotide reductase subunit switching in hepatoblastoma drug response and relapse
Prognosis of children with high-risk hepatoblastoma (HB), the most common pediatric liver cancer, remains poor. In this study, we found ribonucleotide reductase (RNR) subunit M2 (RRM2) was one of the key genes su...
-
Article
Open AccessLoss of phosphatase CTDNEP1 potentiates aggressive medulloblastoma by triggering MYC amplification and genomic instability
MYC-driven medulloblastomas are highly aggressive childhood brain tumors, however, the molecular and genetic events triggering MYC amplification and malignant transformation remain elusive. Here we report that mu...
-
Article
Network-based assessment of HDAC6 activity predicts preclinical and clinical responses to the HDAC6 inhibitor ricolinostat in breast cancer
Inhibiting individual histone deacetylase (HDAC) is emerging as well-tolerated anticancer strategy compared with pan-HDAC inhibitors. Through preclinical studies, we demonstrated that the sensitivity to the le...
-
Chapter and Conference Paper
A Pipelined Arithmetic Architecture for the Motion Planning of Multi-DOF Manipulator
This paper presents a pipelined arithmetic architecture for the motion planning of a multi-DOF manipulator. The architecture starts from the complexity of the motion planning algorithm and the requirement for ...
-
Article
Open AccessEpigenetic activation of the FLT3 gene by ZNF384 fusion confers a therapeutic susceptibility in acute lymphoblastic leukemia
FLT3 is an attractive therapeutic target in acute lymphoblastic leukemia (ALL) but the mechanism for its activation in this cancer is incompletely understood. Profiling global gene expression in large ALL cohorts...
-
Article
Open AccessSmurf2 inhibition enhances chemotherapy and radiation sensitivity in non-small-cell lung cancer
Lung cancer has been the most common cancer worldwide for several decades. The outcomes of patients with locally advanced lung cancer remain dismal, and only a minority of patients survive more than 5 years. H...
-
Article
Open AccessInhibition of mitochondrial complex I reverses NOTCH1-driven metabolic reprogramming in T-cell acute lymphoblastic leukemia
T-cell acute lymphoblastic leukemia (T-ALL) is commonly driven by activating mutations in NOTCH1 that facilitate glutamine oxidation. Here we identify oxidative phosphorylation (OxPhos) as a critical pathway for ...
-
Chapter
Fundamentals of Mathematics and Physics
In engineering field, some engineering problems can be solved by using arithmetic and algebra.
-
Chapter
Instrumentation and Control
Instrument and control refers to the automatic control of the controlled variable. It will measure the signal with a given value, and then the deviation signal will be determined using control method. The outp...
-
Chapter
Radiation Protection
Radiation is the energy of electromagnetic waves or particles in the form of outward diffusion phenomena.
-
Chapter
Material Science
Materials science is the subject of the relationship between the material composition, structure, processing, properties, and performance, as well as to provide scientific basis for the design, materials, manu...
-
Chapter
Heat Transfer
Heat transfer is the science of study of heat transfer laws. Mainly the law of heat transfer caused by temperature difference.
-
Chapter
Electrical Science
Electrical theory and electrical systems are very important in the operation, maintenance and technical support of nuclear engineering, especially nuclear power plants.
-
Chapter
Reactor Theory
Nuclear reactor, or simply the reactor, is able to maintain a controlled, self-sustaining nuclear fission chain reaction in order to achieve the use of nuclear energy. The principles of a nuclear reactor theor...
