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Open AccessTwo-pore channel blockade by phosphoinositide kinase inhibitors YM201636 and PI-103 determined by a histidine residue near pore-entrance
Human two-pore channels (TPCs) are endolysosomal cation channels and play an important role in NAADP-evoked Ca2+ release and endomembrane dynamics. We found that YM201636, a PIKfyve inhibitor, potently inhibits P...
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Open AccessLsm12 is an NAADP receptor and a two-pore channel regulatory protein required for calcium mobilization from acidic organelles
Nicotinic acid adenine dinucleotide phosphate (NAADP) is a potent Ca2+-mobilizing second messenger which uniquely mobilizes Ca2+ from acidic endolysosomal organelles. However, the molecular identity of the NAADP ...
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Article
Open AccessMolecular determinants of Ca2+ sensitivity at the intersubunit interface of the BK channel gating ring
The large-conductance calcium-activated K+ (BK) channel contains two intracellular tandem Ca2+-sensing RCK domains (RCK1 and RCK2), which tetramerize into a Ca2+ gating ring that regulates channel opening by conf...
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Article
Open AccessRelationship between auxiliary gamma subunits and mallotoxin on BK channel modulation
The large-conductance, calcium- and voltage-activated K+(BK) channel consists of the pore-forming α subunits (BKα) and auxiliary subunits. The auxiliary γ1-3 subunits potently modulate the BK channel by shifting ...
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Article
LRRC26 auxiliary protein allows BK channel activation at resting voltage without calcium
BK (or 'big potassium') channels are a type of large-conductance calcium- and voltage-activated potassium channel that is important for the physiology of many different cell types. These channels have a wide t...
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Chapter 6 The Enigmatic Chlorophyll a Molecule in the Cytochrome b 6 f Complex
The structure of the cytochrome b 6 f complex, which functions in the “dark” reactions of oxygenic photosynthesis contains two pigment molecules, one molecule of chlorophyll a and β-ca...
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Structure of the cytochrome b6f complex: new prosthetic groups, Q-space, and the ‘hors d’oeuvres hypothesis’ for assembly of the complex
3-Å crystal structures of the cytochrome b6f complex have provided a structural framework for the photosynthetic electron transport chain. The structures of the 220,000 molecular weight dimeric cytochrome b6f com...
