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    Article

    Congenital iRHOM2 deficiency causes ADAM17 dysfunction and environmentally directed immunodysregulatory disease

    We report a pleiotropic disease due to loss-of-function mutations in RHBDF2, the gene encoding iRHOM2, in two kindreds with recurrent infections in different organs. One patient had recurrent pneumonia but no ...

    Satoshi Kubo, Jill M. Fritz, Hayley M. Raquer-McKay, Rhea Kataria… in Nature Immunology (2022)

  2. Article

    A guide to cancer immunotherapy: from T cell basic science to clinical practice

    The T lymphocyte, especially its capacity for antigen-directed cytotoxicity, has become a central focus for engaging the immune system in the fight against cancer. Basic science discoveries elucidating the mol...

    Alex D. Waldman, Jill M. Fritz, Michael J. Lenardo in Nature Reviews Immunology (2020)

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