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  1. No Access

    Article

    Function of Long Noncoding RNAs in Glioma Progression and Treatment Based on the Wnt/β-Catenin and PI3K/AKT Signaling Pathways

    Gliomas are a deadly primary malignant tumor of the central nervous system, with glioblastoma (GBM) representing the most aggressive type. The clinical prognosis of GBM patients remains bleak despite the avail...

    Hanyun Li, Jilan Liu, **anyun Qin, Jikui Sun… in Cellular and Molecular Neurobiology (2023)

  2. No Access

    Article

    Correction of chromosomal point mutations in human cells with bifunctional oligonucleotides

    A sequence-specific genomic delivery system for the correction of chromosomal mutations was designed by incorporating two different binding domains into a single-stranded oligonucleotide. A repair domain (RD) ...

    Kenneth W. Culver, Wang-Ting Hsieh, Yentram Huyen, Vivian Chen… in Nature Biotechnology (1999)

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    Article

    Targeted gene knockout mediated by triple helix forming oligonucleotides

    Triple helix forming oligonucleotides (TFOs) recognize and bind sequences in duplex DNA and have received considerable attention because of their potential for targeting specific genomic sites ...

    Alokes Majumdar, Alexander Khorlin, Natalia Dyatkina, F.-L. Michael Lin… in Nature Genetics (1998)