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Article
Open AccessGenome wide-scale CRISPR-Cas9 knockout screens identify a fitness score for optimized risk stratification in colorectal cancer
The molecular complexity of colorectal cancer poses a significant challenge to the clinical implementation of accurate risk stratification. There is still an urgent need to find better biomarkers to enhance es...
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Article
Open AccessAssociation among abnormal glycolipids, reproductive hormones, and cognitive dysfunction in female patients with bipolar disorder
Patients with bipolar disorder (BD) show abnormalities in glucolipid metabolism and reproductive hormone levels, which are of concern in women with BD. This study was dedicated to investigating the glucolipid ...
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Article
Open AccessAssociation of childhood trauma, social support, cognition, and suicidality in females with bipolar disorder
Bipolar disorder (BD) is a severe mental disorder with heavy disease burden. Females with BD are special populations who suffer a lot from childhood trauma, social support, cognitive deficits, and suicidality....
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Article
Open AccessLean body mass positively associate with blood pressure in Chinese adults: the roles of ages and body fat distribution
The relationship between lean body mass (LBM) and blood pressure (BP) is controversial and limited. This study investigated the associations between LBM indexes and BP in adults of different ages and with vary...
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Article
Modification of size cutoff for biopsy based on the American College of Radiology Thyroid Imaging Reporting and Data System (TI-RADS) for thyroid nodules in patients younger than 19 years
To modify the size cutoff for biopsy for thyroid nodules in patients < 19 years based on the American College of Radiology Thyroid Imaging Reporting and Data System (TI-RADS) and evaluate the performance of th...
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Article
Open AccessLong-term exposure to exogenous phthalate, masculinity and femininity trait, and gender identity in children: a Chinese 3-year longitudinal cohort study
Phthalate esters (PAEs) are known to have hormone-like properties, and there is a growing trend of children expressing a gender identity different from assigned sex. However, there has been limited research in...
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Article
Open AccessComparison of the diagnostic efficiency between the O-RADS US risk stratification system and doctors’ subjective judgment
This study aimed to compare the diagnostic efficiency of Ovarian-Adnexal Reporting and Data System (O-RADS) and doctors’ subjective judgment in diagnosing the malignancy risk of adnexal masses.
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Article
Association of body fat distribution with high blood pressure among Chinese children and adolescents with various nutritional status: a population-based study
To investigate the associations between body fat distribution and high blood pressure (HBP) in children and adolescents with different nutritional status.
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Article
Realgar-Induced Neurotoxicity: Crosstalk Between the Autophagic Flux and the p62-NRF2 Feedback Loop Mediates p62 Accumulation to Promote Apoptosis
Realgar is a traditional Chinese medicine that contains arsenic. It has been reported that the abuse of medicine-containing realgar has potential central nervous system (CNS) toxicity, but the toxicity mechani...
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Article
Open AccessMaresin-1 inhibits high glucose induced ferroptosis in ARPE-19 cells by activating the Nrf2/HO-1/GPX4 pathway
Maresin-1 plays an important role in diabetic illnesses and ferroptosis is associated with pathogenic processes of diabetic retinopathy (DR). The goal of this study is to explore the influence of maresin-1 on ...
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Article
Open AccessA cluster randomized trial of a comprehensive intervention nesting family and clinic into school centered implementation to reduce myopia and obesity among children and adolescents in Bei**g, China: study protocol
Myopia and obesity in children and adolescents have become serious public health problems that endanger public health, especially in China. Unhealthy lifestyle behaviors are environmental drivers of both myopi...
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Open AccessEnhancing the effectiveness of infectious disease health education for children and adolescents in China: a national multicenter school-based trial
Infectious diseases pose a significant risk to the health and well-being of children and adolescents, and can even be life-threatening. Thus, our study aimed to explore the effectiveness of health education ba...
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Article
Effect of coal preparation on atmospheric emissions of trace elements and their cross-media environmental risk from Chinese coal-fired industrial boilers
Coal preparation, which aims to reduce ash and sulfur contents and increase the heating value of coal, is expected to play a significant role in removing toxic trace elements (TEs) before coal combustion. In t...
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Article
Open AccessLINP1 represses unfolded protein response by directly inhibiting eIF2α phosphorylation to promote cutaneous squamous cell carcinoma
Endoplasmic reticulum stress (ER stress) may destroy endoplasmic reticulum homeostasis (ER homeostasis) and leads to programmable cell death. Unfolded protein response (UPR) originally stimulated by ER stress ...
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Article
Open AccessIdentification of marine natural product Pretrichodermamide B as a STAT3 inhibitor for efficient anticancer therapy
The Janus kinase (JAK)/signal transducer and activator of transcription 3 (STAT3) regulates the expression of various critical mediators of cancer and is considered as one of the central communication nodes in...
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Article
Open AccessResveratrol rescues cutaneous radiation-induced DNA damage via a novel AMPK/SIRT7/HMGB1 regulatory axis
Cutaneous radiation injury (CRI) interrupts the scheduled process of radiotherapy and even compromises the life quality of patients. However, the current clinical options for alleviating CRI are relatively lim...
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Article
Prepubertal BMI, pubertal growth patterns, and long-term BMI: Results from a longitudinal analysis in Chinese children and adolescents from 2005 to 2016
To assess the effects of prepubertal BMI on pubertal growth patterns, and the influence of prepubertal BMI and pubertal growth patterns on long-term BMI among Chinese children and adolescents.
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Article
Effectiveness of a body shape index in predicting pediatric high blood pressure
A body shape index (ABSI) is an emerging anthropometric indicator, challenging two traditional parameters: body mass index (BMI) and waist circumference (WC). We aimed to systematically compare and validate th...
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Article
Open AccessSALIS transcriptionally represses IGFBP3/Caspase-7-mediated apoptosis by associating with STAT5A to promote hepatocellular carcinoma
Hepatocellular carcinoma (HCC) is the most common subtype of liver cancer and the second most fatal cancer in the world despite the great therapeutic advances in the past two decades, which reminds us of the g...
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Article
Mercury distribution and emission reduction potentials of Chinese coal-fired industrial boilers
Coal-fired industrial boilers (CFIBs) are an important emission source of mercury. In this study, the mercury flow of the CFIBs in China, including mercury input and output (atmospheric mercury and mercury-con...
