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Article
Covalent post-synthetic modification of MOFs as a fluorescent sensor for the efficient detection of the biomarker of cystinuria
Cystinuria is a genetic disorder, and in severe cases, it might lead to kidney failure. As an important biomarker for cystinuria, the level of arginine (Arg) in urine is a vital indicator for cystinuria screen...
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Article
Synthesis of 2,3-dihydro-1,4-benzoxathiine derivatives
2,3-Dihydro-1,4-benzoxathiine derivatives are important biologically active heterocyclic compounds. Approaches toward synthesis of 2,3-dihydro-1,4-benzoxathiine derivatives are summarized in this minireview, c...
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Article
AT1 Receptors: Their Actions from Hypertension to Cognitive Impairment
Hypertension is one of the most prevalent cardiovascular disorders worldwide, affecting 1.13 billion people, or 14% of the global population. Hypertension is the single biggest risk factor for cerebrovascular ...
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Article
Expression of ACE2 in Human Neurons Supports the Neuro-Invasive Potential of COVID-19 Virus
The recent outbreak of 2019 coronavirus disease (COVID-19), caused by a novel coronavirus, has now spread quickly worldwide. Like the severe acute respiratory syndrome coronavirus (SARS-CoV), this novel type o...
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Article
Open AccessDiblock dialternating terpolymers by one-step/one-pot highly selective organocatalytic multimonomer polymerization
The synthesis of well-defined block copolymers from a mixture of monomers without additional actions (“one-pot/one-step”) is an ideal and industrially valuable method. In addition, the presence of controlled a...
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Article
Synthetic application of oxiranecarbonitriles (microreview)
The microreview covers synthetic applications of oxiranecarbonitriles that are summarized in five distinct categories: ring opening, ring expansion, Meinwald rearrangement, cycloaddition, and enzyme hydrolysis.
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Article
Synthesis and application of azacycloalk-1-ene-fused oxazol-3-ium salts (microreview)
Synthesis and application of azacycloalk-1-enefused oxazol-3-ium salts are summarized. The microreview covers all synthetic methods for obtaining 6,7-dihydro-5H-pyrrolo[2,1-b]oxazol-4-ium and 5,6,7,8-tetrahydroox...
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Article
Synthesis and stability of thermally labile 1,2-oxaphosphetane 2-oxides and 1,2-thiaphosphetane 2-sulfides (microreview)
Synthesis and thermal stability of 1,2-oxaphosphetane 2-oxide and 1,2-thiaphosphetane 2-sulfide derivatives are discussed. This microreview covers the available synthetic methods of thermally labile 1,2-oxaph...
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Article
Synthesis of 1,2-azaphosphetidine 2-oxides/sulfides (microreview)
All reported approaches toward synthesis of 1,2-azaphosphetidine 2-oxide/sulfide derivatives are summarized. Synthetic methods for 1,2-azaphosphetidine 2-oxides/sulfides are gathered in four categories: ring e...
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Article
Excessive Glutamate Stimulation Impairs ACE2 Activity Through ADAM17-Mediated Shedding in Cultured Cortical Neurons
The excitotoxicity of glutamate plays an important role in the progression of various neurological disorders via participating in inflammation and neuronal damage. In this study, we identified the role of exce...
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Article
Mechanistic insight into thermal 1,3- and 1,5-sulfonyl migrations of N-arenesulfonylphenothiazines and N-arenesulfonylphenoxazines
The substrate scope and mechanistic insight of the thermal-induced 1,3- and 1,5-sulfonyl migration reactions of various sulfonamides have been investigated. The results indicate that both N-arenesulfonylphenothia...
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Article
Chemospecific synthesis of 2-acetoxyindole-3-carbonitriles catalyzed by Cu(acac)2
A chemospecific one-pot synthesis of easily isolable 2-acetoxyindole-3-carbonitriles was described. The intermediate 2-oxindole-3-carbonitriles successfully prepared from 2-cyano diazoacetanilides without isol...
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Chapter
Synthesis of Four- to Seven-Membered Heterocycles by Ring Expansion: Ring Expansions of Thiiranes and Thietanes
Thiiranes and thietanes are important intermediates in organic synthesis, just as their oxygen and nitrogen analogs (oxiranes and aziridines, and oxetanes and azetidines). They have been widely applied in the ...
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Article
Characterization of the effects of Cl− channel modulators on TMEM16A and bestrophin-1 Ca2+ activated Cl− channels
The Ca2+ activated Cl− channels (CaCCs) play a multitude of important physiological functions. A number of candidate proteins have been proposed to form CaCC, but only two families, the bestrophins and the TMEM16...
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Article
Theoretical insights into the [4 + 2]/retro [4 + 2] cycloaddition approach to the synthesis of biaryls and polycyclic aromatics
A domino [4 + 2]/retro [4 + 2] cycloaddition process of cyclohexadienes with arylethynes or benzyne providing access to biaryls and polycyclic aromatics has been studied theoretically using density functional ...
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Article
Theoretical studies on selectivities in the Staudinger reaction of vicinal diimines and ketenes
The selectivities, including peri-, regio-, and diastereoselectivities, in the Staudinger reaction involving vicinal diimines and ketenes were investigated theoretically via the density functional theory (DFT)...
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Article
An efficient and facile synthesis of N-Cbz-β-aminoalkanesulfonamides
An efficient method for the synthesis of N-Cbz-β-aminoalkanesulfonamides was described. N-Cbz-β-aminoalkanesulfona-mides were readily prepared in good yields from a variety of amino alcohols, including optically ...
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Article
Facile synthesis of hybrid sulfonophosphinodipeptides composing of taurines and 1-aminoalkylphosphinic acids
Both sulfonopeptides and phosphonopeptides are important analogs of naturally occurring peptides and have been widely used as enzyme inhibitors and haptens for producing catalytic antibodies due to their tetra...
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Article
Stereoselective synthesis of cis- and trans-4-acyl-β-lactams from vicinal diketones and ketoaldehydes
4-Acyl-β-lactams are important synthetic intermediates in both pharmaceutical and organic chemistry. Cis- and trans-4-acyl-β-lactams were synthesized stereoselectively from vicinal diketones via the formation of ...
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Article
Versatile synthesis of α-substituted taurines from nitroolefins
A series of 1-substituted and 1,1-disubstituted taurines were synthesized from nitroolefins via the Michael addition with sodium ethylxanthate, oxidation with performic acid, and reduction with hydrogen in the...
