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  1. Article

    Open Access

    Nrf2 drives oxidative stress-induced autophagy in nucleus pulposus cells via a Keap1/Nrf2/p62 feedback loop to protect intervertebral disc from degeneration

    Intervertebral disc (IVD) degeneration is known to aggravate with age and oxidative stress is implicated in the pathogenesis of many age-related diseases. Nuclear factor (erythroid-derived-2)-like 2 (Nrf2) can...

    Zehan Tang, Bo Hu, Fazhi Zang, Jianxi Wang, **ngda Zhang… in Cell Death & Disease (2019)

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  2. No Access

    Article

    A near-infrared fluorescent probe based on chloroacetate modified naphthofluorescein for selectively detecting cysteine/homocysteine and its application in living cells

    We have prepared a near-infrared (NIR) turn-on fluorescent probe (NFC) based on chloroacetate modified naphthofluorescein for specific detection of cysteine (Cys) and homocysteine (Hcy) over glutathione (GSH) and...

    Jianxi Wang, Cheng Zhou, Wei Liu… in Photochemical & Photobiological Sciences (2016)

  3. No Access

    Article

    MiR-34a promotes Fas-mediated cartilage endplate chondrocyte apoptosis by targeting Bcl-2

    Apoptosis of cartilage endplate (CEP) chondrocytes is associated with the pathogenesis of intervertebral disk degeneration (IDD). Recent studies have shown that miR-34a is crucially involved in chondrocyte apo...

    Huajiang Chen, Jianxi Wang, Bo Hu, **aodong Wu… in Molecular and Cellular Biochemistry (2015)