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Article
Open AccessTea polyphenol-derived nanomedicine for targeted photothermal thrombolysis and inflammation suppression
Thrombotic diseases impose a significant global health burden, and conventional drug-based thrombolytic therapies are encumbered by the risk of bleeding complications. In this study, we introduce a novel drug-...
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Article
Open AccessA computational spatial whole-Cell model for hepatitis B viral infection and drug interactions
Despite a vaccine, hepatitis B virus (HBV) remains a world-wide source of infections and deaths. We develop a whole-cell computational platform combining spatial and kinetic models describing the infection cyc...
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Article
Open AccessM2 tumor-associated macrophage mediates the maintenance of stemness to promote cisplatin resistance by secreting TGF-β1 in esophageal squamous cell carcinoma
Esophageal squamous cell carcinoma (ESCC) is a deadly gastrointestinal malignancy, and chemotherapy resistance is a key factor leading to its poor prognosis. M2 tumor-associated macrophages (M2-TAMs) may be an...
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Article
A roadmap for serum biomarkers for hepatitis B virus: current status and future outlook
Globally, 296 million people are infected with hepatitis B virus (HBV), and approximately one million people die annually from HBV-related causes, including liver cancer. Although there is a preventative vacci...
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Article
Open AccessAssociation of tumour-associated macrophages with cancer cell EMT, invasion, and metastasis of Kazakh oesophageal squamous cell cancer
Tumour-associated macrophages (TAMs) play an important role in the growth, progression, and metastasis of tumours. Epithelial-mesenchymal transition (EMT) is a mechanism for tumour invasion and metastasis. In ...
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Article
Open AccessEpigenetically upregulated oncoprotein PLCE1 drives esophageal carcinoma angiogenesis and proliferation via activating the PI-PLCε-NF-κB signaling pathway and VEGF-C/ Bcl-2 expression
Esophageal squamous cell carcinoma (ESCC) is one of the most lethal malignancies. Neovascularization during tumorigenesis supplies oxygen and nutrients to proliferative tumor cells, and serves as a conduit for...
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Article
Open AccessMinicircle HBV cccDNA with a Gaussia luciferase reporter for investigating HBV cccDNA biology and develo** cccDNA-targeting drugs
Chronic Hepatitis B Virus (HBV) infection is generally not curable with current anti-viral drugs. Virus rebounds after stop** treatment from the stable HBV covalently-closed-circular DNA (cccDNA). The develo...
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Article
Open AccessMembrane type 1-matrix metalloproteinase induces epithelial-to-mesenchymal transition in esophageal squamous cell carcinoma: Observations from clinical and in vitro analyses
Membrane type 1-matrix metalloproteinase (MT1-MMP) is associated with enhanced tumorigenicity in many cancers. A recent study has revealed that MT1-MMP induces epithelial-to-mesenchymal transition (EMT) in pro...
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Article
Open AccessHeterozygote of TAP1 Codon637 decreases susceptibility to HPV infection but increases susceptibility to esophageal cancer among the Kazakh populations
The role of human papillomavirus (HPV) may be involved in the development of esophageal cancer (EC) and the polymorphic immune response gene transporter associated with antigen processing (TAP) may be involved...
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Article
Open AccessInactivation of miR-34a by aberrant CpG methylation in Kazakh patients with esophageal carcinoma
Esophageal squamous cell carcinoma (ESCC) is an aggressive tumor with dismal prognosis and high incidence and mortality in Kazakh population. MiR-34a, a direct p53 target gene, possesses tumor-suppressive prop...
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Chapter and Conference Paper
Locating segmentation regions of connected handwritten digits
Segmentation of handwritten touching characters is an important research topic in Optical Character Recognition (OCR). Finding the initial candidate segmentation points is the first important step. A method is...
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Chapter and Conference Paper
Structural boundary feature extraction for printed character recognition
In this paper, an algorithm is developed for printed character recognition based on boundary analysis. New boundary smoothing schemes have been proposed, which can reduce noise significantly. The extracted bou...
