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Article
Open AccessTea polyphenol-derived nanomedicine for targeted photothermal thrombolysis and inflammation suppression
Thrombotic diseases impose a significant global health burden, and conventional drug-based thrombolytic therapies are encumbered by the risk of bleeding complications. In this study, we introduce a novel drug-...
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Article
CAV driving safety monitoring and warning via V2X-based edge computing system
Driving safety and accident prevention are attracting increasing global interest. Current safety monitoring systems often face challenges such as limited spatiotemporal coverage and accuracy, leading to delays...
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Article
Open AccessA computational spatial whole-Cell model for hepatitis B viral infection and drug interactions
Despite a vaccine, hepatitis B virus (HBV) remains a world-wide source of infections and deaths. We develop a whole-cell computational platform combining spatial and kinetic models describing the infection cyc...
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Article
HPV 16 E6 promotes growth and metastasis of esophageal squamous cell carcinoma cells in vitro
Esophageal squamous cell carcinoma (ESCC) is one of the most lethal malignancies worldwide. Increasing evidence suggests that human papillomavirus (HPV) infection may be associated with the etiology of ESCC. H...
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Article
Joining of carbon nanotube fiber by nickel–copper double-layer metal via two-step meniscus-confined localized electrochemical deposition
Carbon nanotube fiber is a promising material in electrical and electronic applications, such as, wires, cables, batteries, and supercapacitors. But the problem of joining carbon nanotube fiber is a main obsta...
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Article
Open AccessM2 tumor-associated macrophage mediates the maintenance of stemness to promote cisplatin resistance by secreting TGF-β1 in esophageal squamous cell carcinoma
Esophageal squamous cell carcinoma (ESCC) is a deadly gastrointestinal malignancy, and chemotherapy resistance is a key factor leading to its poor prognosis. M2 tumor-associated macrophages (M2-TAMs) may be an...
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Article
Nomenclature of HBV core protein-targeting antivirals
Hepatitis B virus (HBV) core protein-targeting compounds are in or entering clinical development without a standardized nomenclature. We propose a naming convention for these core-targeting antiviral products ...
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Article
A roadmap for serum biomarkers for hepatitis B virus: current status and future outlook
Globally, 296 million people are infected with hepatitis B virus (HBV), and approximately one million people die annually from HBV-related causes, including liver cancer. Although there is a preventative vacci...
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Article
Radiomics-based model using gadoxetic acid disodium-enhanced MR images: associations with recurrence-free survival of patients with hepatocellular carcinoma treated by surgical resection
To develop a prediction model that combined magnetic resonance images (MRI)-based radiomics features with clinical factors to predict recurrence-free survival (RFS) of hepatocellular carcinoma (HCC) patients t...
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Article
Open AccessAssociation of tumour-associated macrophages with cancer cell EMT, invasion, and metastasis of Kazakh oesophageal squamous cell cancer
Tumour-associated macrophages (TAMs) play an important role in the growth, progression, and metastasis of tumours. Epithelial-mesenchymal transition (EMT) is a mechanism for tumour invasion and metastasis. In ...
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Article
Open AccessEpigenetically upregulated oncoprotein PLCE1 drives esophageal carcinoma angiogenesis and proliferation via activating the PI-PLCε-NF-κB signaling pathway and VEGF-C/ Bcl-2 expression
Esophageal squamous cell carcinoma (ESCC) is one of the most lethal malignancies. Neovascularization during tumorigenesis supplies oxygen and nutrients to proliferative tumor cells, and serves as a conduit for...
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Chapter
HIV–HBV and HIV–HCV Coinfection and Liver Cancer Development
Liver diseases that are caused by the hepatitis B virus (HBV) and hepatitis C virus (HCV), including cirrhosis and hepatocellular carcinoma (HCC), have become increasingly important in patients infected with t...
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Protocol
In Vitro Assays for RNA Binding and Protein Priming of Hepatitis B Virus Polymerase
The hepatitis B virus (HBV) polymerase synthesizes the viral DNA genome from the pre-genomic RNA (pgRNA) template through reverse transcription. Initiation of viral DNA synthesis is accomplished via a novel pr...
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Article
Open AccessMinicircle HBV cccDNA with a Gaussia luciferase reporter for investigating HBV cccDNA biology and develo** cccDNA-targeting drugs
Chronic Hepatitis B Virus (HBV) infection is generally not curable with current anti-viral drugs. Virus rebounds after stop** treatment from the stable HBV covalently-closed-circular DNA (cccDNA). The develo...
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Article
Open AccessMembrane type 1-matrix metalloproteinase induces epithelial-to-mesenchymal transition in esophageal squamous cell carcinoma: Observations from clinical and in vitro analyses
Membrane type 1-matrix metalloproteinase (MT1-MMP) is associated with enhanced tumorigenicity in many cancers. A recent study has revealed that MT1-MMP induces epithelial-to-mesenchymal transition (EMT) in pro...
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Article
Open AccessHeterozygote of TAP1 Codon637 decreases susceptibility to HPV infection but increases susceptibility to esophageal cancer among the Kazakh populations
The role of human papillomavirus (HPV) may be involved in the development of esophageal cancer (EC) and the polymorphic immune response gene transporter associated with antigen processing (TAP) may be involved...
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Article
Open AccessInactivation of miR-34a by aberrant CpG methylation in Kazakh patients with esophageal carcinoma
Esophageal squamous cell carcinoma (ESCC) is an aggressive tumor with dismal prognosis and high incidence and mortality in Kazakh population. MiR-34a, a direct p53 target gene, possesses tumor-suppressive prop...
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Article
HLA-DRB1*1501 and HLA-DQB1*0301 alleles are positively associated with HPV16 infection–related Kazakh esophageal squamous cell carcinoma in **njiang China
Multiple determinant factors are involved in the occurrence and progression of esophageal squamous cell carcinoma (ESCC). Human papillomavirus (HPV) and human leukocyte antigen (HLA) polymorphism were identifi...
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Chapter and Conference Paper
Kinematic Modeling of a Heavy-Duty Forging Manipulator
In this paper, a number of kinematics problems of a heavy-duty forging manipulator are studied. The closed-form inverse and forward kinematic equations are established. Secondly, based on hierarchical modeling...
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Article
Structural and electronic properties of tungsten trioxides: from cluster to solid surface
Geometries and electronic structures of WO3(001) surface and a series of stoichiometric (WO3) n clusters (n = 1–6) have been systematically investigated using first-principles d...
