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3,030 Result(s)
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Article
Investigating the Impact of Ocean Acidification on Anti-Stress Mechanisms in Sepia esculenta Larvae Based on Transcriptome Profiling
With the rapid development of oil, energy, power and other industries, CO2 emissions rise sharply, which will cause a large amount of CO2 in the air be absorbed by the ocean and lead to ocean acidification. The g...
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Article
Open AccessNusinersen effectiveness and safety in pediatric patients with 5q-spinal muscular atrophy: a multi-center disease registry in China
To evaluate the effectiveness and safety of nusinersen for the treatment of 5q-spinal muscular atrophy (SMA) among Chinese pediatric patients.
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Article
Integrated Information for Pathogenicity and Treatment of Spiroplasma
Spiroplasma, belonging to the class Mollicutes, is a small, helical, motile bacterium lacking a cell wall. Its host range includes insects, plants, and aquatic crustaceans. Recently, a few human cases of Spiropla...
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Mechanism Analysis of Selenium-Containing Compounds in Alleviating Spinal Cord Injury Based on Network Pharmacology and Molecular Docking Technology
Spinal cord injury (SCI) is a severe traumatic condition in spinal surgery characterized by nerve damage in and below the injured area. Despite advancements in understanding the pathophysiology of SCI, effecti...
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Open AccessSuppressing SENP1 inhibits esophageal squamous carcinoma cell growth via SIRT6 SUMOylation
Esophageal squamous cell carcinoma (ESCC) is a prevalent tumor in the gastrointestinal tract, but our understanding of the molecular mechanisms underlying ESCC remains incomplete. Existing studies indicate tha...
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Open AccessA Post-Marketing Surveillance Study of Nusinersen for Spinal Muscular Atrophy in Routine Medical Practice in China: Interim Results
Spinal muscular atrophy (SMA) is a rare, autosomal recessive, neuromuscular disease that leads to progressive muscular weakness and atrophy. Nusinersen, an antisense oligonucleotide, was approved for SMA in Ch...
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Open AccessEntry of ZSWIM4 to the nucleus is crucial for its inhibition of KIT and BMAL1 in gastrointestinal stromal tumors
Zinc finger SWIM-type containing 4 (ZSWIM4) is a zinc finger protein with its function largely uncharacterized. In this study, we aimed to investigate the role of ZSWIM4 in gastrointestinal stromal tumors (GIS...
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Correction to: Predicting thoracic kyphosis morphology and the thoracolumbar inflection point determined by individual lumbar lordosis in asymptomatic adults
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Research progress on rolling superlubricity in solid lubricants
Superlubricity is an ideal lubrication state where friction nearly vanishes between contact interfaces. It has become one of the most important research topics and approaches owing to its significance in reduc...
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Open AccessMXene-based all-solid flexible electrochromic microsupercapacitor
With the increasing demand for multifunctional optoelectronic devices, flexible electrochromic energy storage devices are being widely recognized as promising platforms for diverse applications. However, simul...
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Open AccessDetection of COVID-19 by quantitative analysis of carbonyl compounds in exhaled breath
COVID-19 has caused a worldwide pandemic, creating an urgent need for early detection methods. Breath analysis has shown great potential as a non-invasive and rapid means for COVID-19 detection. The objective ...
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Article
Engineering S-scheme W18O49/ZnIn2S4 heterojunction by CoxP nanoclusters for enhanced charge transfer capability and solar hydrogen evolution
Enhancement of the light-absorption response and utilization of the photogenerated carriers represent a robust strategy for the design of high-performance photocatalyst. In this work, grafting CoxP nanoclusters o...
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Article
Exportin 1 governs the immunosuppressive functions of myeloid-derived suppressor cells in tumors through ERK1/2 nuclear export
Myeloid-derived suppressor cells (MDSCs) are a main driver of immunosuppression in tumors. Understanding the mechanisms that determine the development and immunosuppressive function of these cells could provid...
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Calculation of Precast Prestressed Beam with Variable Cross-Sections on Pasternak Foundation under Anchoring Force
The precast prestressed frame beams with variable cross-sections and anchor cables are a novel support system in slope reinforcement. To design and construct the novel support system requires calculating inter...
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Open AccessGenome-wide identification and expression analysis of GRAS gene family in Eucalyptus grandis
The GRAS gene family is a class of plant-specific transcription factors with important roles in many biological processes, such as signal transduction, disease resistance and stress tolerance, plant growth and de...
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Article
Tunable electronic and magnetic properties of defective g-ZnO monolayer do** with non-metallic elements
The electronic and magnetic properties of non-metallic (NM) elements do** defective graphene-like ZnO (g-ZnO) monolayer including O vacancy (VO) and Zn vacancy (VZn) are studied. The results show that VO-g-ZnO ...
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Preparation of High-performance Multicrystalline Silicon Ingot Based on Innovative Seeding Strategy for Recycled Seeds
In the preparation of high-performance multicrystalline silicon (HPM-Si) wafers, it is usually necessary to use costly polycrystalline silicon (Poly-Si) as the seed layer. In order to reduce cost and simplify ...
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Replacing soybean meal with fermented rapeseed meal in diets: potential effects on growth performance, antioxidant capacity, and liver and intestinal health of juvenile tilapia (Oreochromis niloticus)
This study aims to evaluate the effects of substituting soybean meal with fermented rapeseed meal (FRM) on growth, antioxidant capacity, and liver and intestinal health of the genetically improved farmed tilap...
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Open AccessThe elite haplotype OsGATA8-H coordinates nitrogen uptake and productive tiller formation in rice
Excessive nitrogen promotes the formation of nonproductive tillers in rice, which decreases nitrogen use efficiency (NUE). Develo** high-NUE rice cultivars through balancing nitrogen uptake and the formation...
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Open AccessInceptCurves: curve reconstruction using an inception network
Curve reconstruction is a fundamental task in many visual computing applications. In this paper, a data-driven approach for curve reconstruction is proposed. We present an inception layered deep neural network...